2-氧吡咯烷-3-甲酸乙酯合成路线 （共 8 条）
反应条件
trifluoroacetic acid in dichloromethane T=0 - 20°C; 1 h;
参考文献
CHUGAI SEIYAKU KABUSHIKI KAISHA
Patent: EP1854792 A1, 2007 ;
Location in patent: Page/Page column 108-109 ;
反应条件
1: 74 percent / NaN3, Et3N*HCl / various solvent(s) / 18 h / 100 °C 2: 81 percent / H2 / 10percent Pd/C / ethanol / 2 h / 1603.2 Torr / Ambient temperature View Scheme
参考文献
Lindstrom, Kyle J.; Crooks, Stephen L.
Synthetic Communications, 1990 , vol. 20, # 15 p. 2335 - 2337
反应条件
ethanol; nickel T=80 - 100°C; P=58840.6 Torr; Hydrogenation;
参考文献
Kato et al.
Nippon Nogei Kagaku Kaishi, 1953 , vol. 27, p. 500
Chem.Abstr., 1955 , p. 3006
反应条件
1: sodium; benzene 2: Raney nickel; ethanol / 80 - 100 °C / 58840.6 Torr / Hydrogenation View Scheme
参考文献
Kato et al.
Nippon Nogei Kagaku Kaishi, 1953 , vol. 27, p. 500
Chem.Abstr., 1955 , p. 3006
参考文献
Kato et al.
Nippon Nogei Kagaku Kaishi, 1953 , vol. 27, p. 500
Chem.Abstr., 1955 , p. 3006
反应条件
sodium tetrahydroborate; calcium chloride in methanol
T=0 - 20°C;
参考文献
Klutchko, Sylvester; Hoefle, Milton L.; Smith, Ronald D.; Essenburg, Arnold D.; Parker, Robert B.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 104 - 109
反应条件
1: 48 percent / CaCl2, sodium borohydride / methanol / 0 - 20 °C
2: 56 percent / CuI, dicyclohexylcabodiimide (DCC) / chlorobenzene / 0.17 h / Heating
View Scheme
参考文献
Klutchko, Sylvester; Hoefle, Milton L.; Smith, Ronald D.; Essenburg, Arnold D.; Parker, Robert B.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 104 - 109
参考文献
Basarab, Gregory S.; Jordan, Douglas B.; Gehret, Troy C.; Schwartz, Rand S.
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 12 p. 4143 - 4154
