3-(3-噻吩)-L-丙氨酸合成路线 （共 6 条）
反应条件
1: NaOAc, Ac2O / 1.5 h / Heating 2: HCl (gas), H2O / dioxane 3: aq. HCl / Heating 4: 40 percent / L-aspartic acid, pyridoxal phosphate, E. coli strain, aq. NaOH View Scheme
参考文献
Meiwes, Johannes; Schudok, Manfred; Kretzschmar, Gerhard
Tetrahedron: Asymmetry, 1997 , vol. 8, # 4 p. 527 - 536
反应条件
1: HCl (gas), H2O / dioxane 2: aq. HCl / Heating 3: 40 percent / L-aspartic acid, pyridoxal phosphate, E. coli strain, aq. NaOH View Scheme
参考文献
Meiwes, Johannes; Schudok, Manfred; Kretzschmar, Gerhard
Tetrahedron: Asymmetry, 1997 , vol. 8, # 4 p. 527 - 536
反应条件
potassium phosphate buffer T=40°C; 24 h; acylase I (E.C. 3.5.1.14, from Aspergillus melleus), pH: 7.5-8;
参考文献
Noe; Weigand; Pirker
Monatshefte fur Chemie, 1996 , vol. 127, # 10 p. 1081 - 1097
反应条件
1: aq. HCl / Heating 2: 40 percent / L-aspartic acid, pyridoxal phosphate, E. coli strain, aq. NaOH View Scheme
参考文献
Meiwes, Johannes; Schudok, Manfred; Kretzschmar, Gerhard
Tetrahedron: Asymmetry, 1997 , vol. 8, # 4 p. 527 - 536
参考文献
SMITH KLINE BEECHAM CORPORATION
Patent: WO2009/32653 A1, 2009 ;
Location in patent: Page/Page column 46 ;
WO 2009/032653 A1
参考文献
Hoffmann-La Roche Inc.
Patent: US5866684 A1, 1999 ;
