2,4-二甲氧基-6-甲基苯甲酸合成路线 （共 39 条）
反应条件
Pd(OTf)2; silver carbonate in dimethyl sulfoxide; N,N-dimethyl-formamide T=100°C;
参考文献
Ouchaou, Kahina; Georgin, Dominique; Taran, Frederic
Synlett, 2010 , # 14 art. no. G18110ST, p. 2083 - 2086
反应条件
aluminium trichloride in chlorobenzene 0.75 h; Heating;
参考文献
Evans, Geoffrey E.; Staunton, James
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 755 - 762
反应条件
sodium hydroxide in ethanol Heating;
参考文献
Wang, Ping; Zhang, Zhaojun; Yu, Biao
Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 8884 - 8889
反应条件
1: CCl4; bromine; N-bromo-succinimide / Irradiation 2: quinoline; copper-powder View Scheme
参考文献
Logan; Newbold
Journal of the Chemical Society, 1957 , p. 1946,1949
反应条件
1.1: 99 percent / DBU / acetonitrile / 20 °C 2.1: LDA / tetrahydrofuran; hexane / 0.33 h / -78 °C 2.2: 70 percent / tetrahydrofuran; hexane / -78 - 20 °C View Scheme
参考文献
Wang, Ping; Zhang, Zhaojun; Yu, Biao
Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 8884 - 8889
反应条件
potassium hydroxide in ethanol
参考文献
Aventis Pharma S.A.
Patent: EP1300403 A1, 2003 ;
反应条件
sodium chlorite; sodium dihydrogenphosphate in water; dimethyl sulfoxide
Ambient temperature;
参考文献
Solladie; Rubio; Carreno; Ruano
Tetrahedron Asymmetry, 1990 , vol. 1, # 3 p. 187 - 198
反应条件
1: 1-bromo-2,4-dimethoxy-6-methylbenzene With n-butyllithium in tetrahydrofuran
T=-78°C; metallation;
2: carbon dioxide T=-78 - 20°C; Carboxylation; Further stages.;
参考文献
Furstner; Thiel; Kindler; Bartkowska
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 7990 - 7995
反应条件
potassium hydroxide in ethanol; water
12 h; Reflux;
参考文献
Zhang, Li; Ma, Wenquan; Xu, Lili; Deng, Fei; Guo, Yuewei
Chinese Journal of Chemistry, 2013 , vol. 31, # 3 p. 339 - 343
反应条件
1.1: 97 percent / NBS / CHCl3 / 1.5 h / 0 °C
2.1: n-BuLi / tetrahydrofuran / -78 °C
2.2: 86 percent / -78 - 20 °C
View Scheme
参考文献
Furstner; Thiel; Kindler; Bartkowska
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 7990 - 7995
