5-(二氟甲氧基)-2-{[(4-氯-3-甲氧基-2-吡啶基)甲基]硫}-1氢-苯并咪唑合成路线 （共 6 条）
反应条件
1: 4-chloro-2-(chloromethyl)-3-methoxypyridine With sodium methylate in methanol; toluene T=15 - 25°C; 1 h; 2: 5-difluoromethoxy-2-mercapto-1H-benzimidazole in methanol; toluene 0.5 h; 3: With sodium methylate in methanol; toluene T=15 - 35°C; 1 h;
参考文献
EP1518857 A1, ;
Page/Page column 5 ;
反应条件
sodium hydroxide in water; toluene T=55 - 65°C; 4 - 6 h;
参考文献
WO2007/12650 A1, ;
Page/Page column 17 ;
反应条件
sodium hydroxide in water; toluene T=55 - 65°C; 4 - 6 h;
参考文献
WO2007/12651 A1, ;
Page/Page column 15-16 ;
反应条件
in methanol T=50°C; Heating / reflux;
参考文献
Dipharma S.p.A.
Patent: EP1518857 A1, 2005 ;
Location in patent: Page/Page column 5-6 ;
反应条件
peracetic acid; sodium hydrogencarbonate; acetic acid in dichloromethane; isopropyl alcohol
T=0 - 5°C;
参考文献
QUIMICA SINTETICA, S. A.
Patent: WO2006/100243 A1, 2006 ;
Location in patent: Page/Page column 11-12 ;
反应条件
ε-phthalimido-peroxy-hexanoic acid in isopropyl alcohol
T=20 - 30°C; 6.5 h;
参考文献
DINAMITE DIPHARMA S.P.A. abbreviated DIPHARMA S.P.A.
Patent: US2004/192929 A1, 2004 ;
Location in patent: Page 3 ;
