3,4-二氟硝基苯合成路线

参考文献

ANACOR PHARMACEUTICALS, INC.; HERNANDEZ, Vincent, S.; DING, Charles; PLATTNER, Jacob; ALLEY, Michael, Richard Kevin; ZHANG, Yong-Kang; ZHANG, Yanchen
Patent: WO2011/37731 A1, 2011 ;

288-32-4咪唑+

369-34-63,4-二氟硝基苯

154164-56-43-氟-4-(1H-咪唑-1-基)硝基苯

参考文献

Genin, Michael J.; Allwine, Debra A.; Anderson, David J.; Barbachyn, Michael R.; Emmert, D. Edward; Garmon, Stuart A.; Graber, David R.; Grega, Kevin C.; Hester, Jackson B.; Hutchinson, Douglas K.; Morris, Joel; Reischer, Robert J.; Ford, Charles W.; Zurenko, Gary E.; Hamel, Judith C.; Schaadt, Ronda D.; Stapert, Douglas; Yagi, Betty H.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 953 - 970

288-32-4咪唑

154164-56-43-氟-4-(1H-咪唑-1-基)硝基苯

参考文献

Pharmacia and Upjohn Company
Patent: US6124334 A1, 2000 ;

123-90-0硫代吗啉+

369-34-63,4-二氟硝基苯

168828-70-4

参考文献

SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/32667 A1, 2009 ;
Location in patent: Page/Page column 109 ;
WO 2009/032667 A1

参考文献

Pharmacia and Upjohn Company
Patent: US5688792 A1, 1997 ;

369-34-63,4-二氟硝基苯

168828-72-6(R)-3-(3-氟-4-硫代吗啉苯基)-5-(羟基甲基)噁唑啉-2-酮

参考文献

Barbachyn, Michael R.; Hutchinson, Douglas K.; Brickner, Steven J.; Cynamon, Michael H.; Kilburn, James O.; et al.
J. Med. Chem., 1996 , vol. 39, # 3 p. 680 - 685

369-34-63,4-二氟硝基苯+

57260-71-61-Boc-哌嗪

154590-34-84-(2-氟-4-硝基苯基)哌嗪-1-羧酸叔丁酯

参考文献

JANSSEN PHARMACEUTICA N.V.
Patent: WO2009/79597 A1, 2009 ;
Location in patent: Page/Page column 58-59 ;

369-34-63,4-二氟硝基苯

154590-34-84-(2-氟-4-硝基苯基)哌嗪-1-羧酸叔丁酯

参考文献

Das, Biswajit; Rudra, Sonali; Yadav, Ajay; Ray, Abhijit; Raja Rao; Srinivas; Soni, Ajay; Saini, Suman; Shukla, Shalini; Pandya, Manisha; Bhateja, Pragya; Malhotra, Sunita; Mathur, Tarun; Arora; Rattan, Ashok; Mehta, Anita
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4261 - 4267

369-34-63,4-二氟硝基苯

154590-62-2(R)-4-(2-氟-4-(5-(羟基甲基)-2-氧代噁唑啉-3-基)苯基)哌嗪-1-羧酸叔丁酯

参考文献

Das, Biswajit; Rudra, Sonali; Yadav, Ajay; Ray, Abhijit; Raja Rao; Srinivas; Soni, Ajay; Saini, Suman; Shukla, Shalini; Pandya, Manisha; Bhateja, Pragya; Malhotra, Sunita; Mathur, Tarun; Arora; Rattan, Ashok; Mehta, Anita
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4261 - 4267

369-34-63,4-二氟硝基苯

221198-99-83-氟-4-(4-甲基-1-哌嗪基)苯胺

参考文献

Patel, Kavitkumar N.; Telvekar, Vikas N.
European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 43 - 56