1: 76 percent / CaCO3 / RhCl3*3H2O / propan-2-ol / 105 °C 2: PhI(OAc)2, I2 / cyclohexane / 50 °C / Irradiation 3: 99 percent / H2 / PtO2 / ethyl acetate / 42 h / 23 °C / 2844.3 Torr 4: RuCl3*H2O, NaIO4 / CCl4; acetonitrile; H2O / 23 °C 5: diethyl ether / 0 °C 6: 89 percent / PhNMe3Br3 / tetrahydrofuran / 23 °C 7: 90 percent / Li2CO3, LiBr / dimethylformamide / 1 h / 80 - 130 °C 8: DIBAL-H / toluene / -78 - 0 °C 9: tetrapropylammonium perruthenate, NMO, 4 Angstroem mol. sieves / CH2Cl2 / 23 °C 10: 91 percent / LiHMDS, Me3SiCl / tetrahydrofuran / -78 °C 11: 91 percent / Davis oxaziridine / CHCl3 / 0 - 23 °C View Scheme

1: 99 percent / H2 / PtO2 / ethyl acetate / 42 h / 23 °C / 2844.3 Torr 2: RuCl3*H2O, NaIO4 / CCl4; acetonitrile; H2O / 23 °C 3: diethyl ether / 0 °C 4: 89 percent / PhNMe3Br3 / tetrahydrofuran / 23 °C 5: 90 percent / Li2CO3, LiBr / dimethylformamide / 1 h / 80 - 130 °C 6: DIBAL-H / toluene / -78 - 0 °C 7: tetrapropylammonium perruthenate, NMO, 4 Angstroem mol. sieves / CH2Cl2 / 23 °C 8: 91 percent / LiHMDS, Me3SiCl / tetrahydrofuran / -78 °C 9: 91 percent / Davis oxaziridine / CHCl3 / 0 - 23 °C View Scheme

1: 2.) AcOH, piperidine / 2.) PhH, reflux 2: 76 percent / CaCO3 / RhCl3*3H2O / propan-2-ol / 105 °C 3: PhI(OAc)2, I2 / cyclohexane / 50 °C / Irradiation 4: 99 percent / H2 / PtO2 / ethyl acetate / 42 h / 23 °C / 2844.3 Torr 5: RuCl3*H2O, NaIO4 / CCl4; acetonitrile; H2O / 23 °C 6: diethyl ether / 0 °C 7: 89 percent / PhNMe3Br3 / tetrahydrofuran / 23 °C 8: 90 percent / Li2CO3, LiBr / dimethylformamide / 1 h / 80 - 130 °C 9: DIBAL-H / toluene / -78 - 0 °C 10: tetrapropylammonium perruthenate, NMO, 4 Angstroem mol. sieves / CH2Cl2 / 23 °C 11: 91 percent / LiHMDS, Me3SiCl / tetrahydrofuran / -78 °C 12: 91 percent / Davis oxaziridine / CHCl3 / 0 - 23 °C View Scheme

1: With selenium(IV) oxide in 1,4-dioxane Alkylation; 2 h; Heating; 2: iso-propylmagnesium bromide; CJ-14,445 in tetrahydrofuran T=0 - 20°C; Alkylation; 4 h;

1: RuCl3*H2O, NaIO4 / CCl4; acetonitrile; H2O / 23 °C 2: diethyl ether / 0 °C 3: 89 percent / PhNMe3Br3 / tetrahydrofuran / 23 °C 4: 90 percent / Li2CO3, LiBr / dimethylformamide / 1 h / 80 - 130 °C 5: DIBAL-H / toluene / -78 - 0 °C 6: tetrapropylammonium perruthenate, NMO, 4 Angstroem mol. sieves / CH2Cl2 / 23 °C 7: 91 percent / LiHMDS, Me3SiCl / tetrahydrofuran / -78 °C 8: 91 percent / Davis oxaziridine / CHCl3 / 0 - 23 °C View Scheme

1: 89 percent / PhNMe3Br3 / tetrahydrofuran / 23 °C 2: 90 percent / Li2CO3, LiBr / dimethylformamide / 1 h / 80 - 130 °C 3: DIBAL-H / toluene / -78 - 0 °C 4: tetrapropylammonium perruthenate, NMO, 4 Angstroem mol. sieves / CH2Cl2 / 23 °C 5: 91 percent / LiHMDS, Me3SiCl / tetrahydrofuran / -78 °C 6: 91 percent / Davis oxaziridine / CHCl3 / 0 - 23 °C View Scheme

1: 91 percent / LiHMDS, Me3SiCl / tetrahydrofuran / -78 °C 2: 91 percent / Davis oxaziridine / CHCl3 / 0 - 23 °C View Scheme

1: DIBAL-H / toluene / -78 - 0 °C 2: tetrapropylammonium perruthenate, NMO, 4 Angstroem mol. sieves / CH2Cl2 / 23 °C 3: 91 percent / LiHMDS, Me3SiCl / tetrahydrofuran / -78 °C 4: 91 percent / Davis oxaziridine / CHCl3 / 0 - 23 °C View Scheme