2-苄基-1,3-噻唑-4-羧酸合成路线 (共 5 条)
反应条件
in tetrahydrofuran T=20°C; 135 h; not specified; Microwave irradiation;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/49018 A1, 2005 ;
Location in patent: Page/Page column 85-86 ;
WO 2005/049018 A1
反应条件
potassium hydroxide T=50°C;
参考文献
Larsen, Scott D.; Stachew, Carl F.; Clare, Paula M.; Cubbage, Jerry W.; Leach, Karen L.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3491 - 3495
反应条件
1: ethanol / 75 °C 2: aq. KOH / 50 °C View Scheme
参考文献
Larsen, Scott D.; Stachew, Carl F.; Clare, Paula M.; Cubbage, Jerry W.; Leach, Karen L.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3491 - 3495
参考文献
Brown
Chem. Penicillin, <Princeton 1949>, S. 473, 497, 524
参考文献
Mozingo; Folkers
Chem. Penicillin, <Princeton 1949>, S. 535, 596