1-甲基-1H-吡咯-3-甲醛合成路线 （共 15 条）
反应条件
sodium hydroxide; silver nitrate
参考文献
Mai; Artico, Marino; Esposito; Ragno; Sbardella; Massa
Farmaco, 2003 , vol. 58, # 3 p. 231 - 241
反应条件
hydrogen; RhH(CO)(triphenylphosphine)3 in benzene
T=100°C; P=76000.1 Torr;
参考文献
Brezhnev, L. Yu.; Vartanyan, M. M.; Vol'f, E. Yu.; Solov'eva, T. Yu.; Rodin, A. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1990 , vol. 26, # 9 p. 1073
Khimiya Geterotsiklicheskikh Soedinenii, 1990 , vol. 26, # 9 p. 1285
反应条件
sodium hydroxide in acetic acid
参考文献
American Cyanamid Company
Patent: US5108485 A1, 1992 ;
反应条件
16-crown-6; potassium tert-butylate in cyclohexane; dimethyl sulfoxide
参考文献
Purkarthofer, Thomas; Gruber, Karl; Fechter, Martin H.; Griengl, Herfried
Tetrahedron, 2005 , vol. 61, # 32 p. 7661 - 7668
反应条件
1: pyrrole-3-carboxaldehyde With potassium hydroxide in dimethyl sulfoxide
T=20°C; 0.833333 h;
2: methyl halide in dimethyl sulfoxide
T=20°C;
参考文献
Valente, Sergio; Tomassi, Stefano; Tempera, Giampiero; Saccoccio, Stefania; Agostinelli, Enzo; Mai, Antonello
Journal of Medicinal Chemistry, 2011 , vol. 54, # 23 p. 8228 - 8232
反应条件
1: N,N-diisopropyl carboxamide With trichlorophosphate in anhydrous dichloroethane
T=0°C; Vilsmeier-Haack reaction; 1 h; Reflux;
2: 1-methyl-pyrrole in anhydrous dichloroethane
T=0°C; Vilsmeier-Haack reaction; 0.25 h; Reflux;
3: With water; sodium acetate in anhydrous dichloroethane
0.5 h; regioselective reaction;
参考文献
Ilyin, Petrv.; Pankova, Alenas.; Kuznetsov, Mikhail A.
Synthesis, 2012 , vol. 44, # 9 p. 1353 - 1358
反应条件
sodium hydroxide; diphosphoric acid tetrachloride
1) 20 deg C, 18 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Downie, Ian M.; Earle, Martyn J.; Heaney, Harry; Shuhaibar, Khamis F.
Tetrahedron, 1993 , vol. 49, # 19 p. 4015 - 4034
反应条件
1: 33 percent / Ambient temperature
2: 6 percent / LiAlH4 / tetrahydrofuran / 4 h / Ambient temperature
View Scheme
参考文献
Abramovitch, Rudolph A.; Chapman, Andrew V.
Heterocycles, 1995 , vol. 40, # 1 p. 89 - 92
反应条件
1: With trichlorophosphate in anhydrous dichloroethane
Vilsmeier-Haack reaction; 1 h; Reflux;
2: With potassium hydroxide in anhydrous dichloroethane; water
0.0166667 h;
参考文献
Ilyin, Petrv.; Pankova, Alenas.; Kuznetsov, Mikhail A.
Synthesis, 2012 , vol. 44, # 9 p. 1353 - 1358
反应条件
1: With trichlorophosphate in anhydrous dichloroethane
Vilsmeier-Haack reaction; 1 h; Reflux;
2: With potassium hydroxide in anhydrous dichloroethane; water
0.0166667 h; regioselective reaction;
参考文献
Ilyin, Petrv.; Pankova, Alenas.; Kuznetsov, Mikhail A.
Synthesis, 2012 , vol. 44, # 9 p. 1353 - 1358
