1-甲基-1H-吡咯-3-羧酸合成路线 （共 6 条）
反应条件
hydrogenchloride; sodium hydroxide; sodium chloride
参考文献
Suntory Limited
Patent: US6258805 B1, 2001 ;
反应条件
methyl aluminum dichloride in hexane; toluene T=20°C; Friedel-Crafts reaction; P=22502.3 Torr; 3 h; regioselective reaction;
参考文献
Nemoto, Koji; Onozawa, Satoru; Egusa, Naoki; Morohashi, Naoya; Hattori, Tetsutaro
Tetrahedron Letters, 2009 , vol. 50, # 31 p. 4512 - 4514
反应条件
sodium hydroxide in methanol Hydrolysis; 6 h; Heating;
参考文献
Mizuno, Akira; Ogata, Atsuto; Kamei, Tomoe; Shibata, Makoto; Shimamoto, Tetsuo; Hayashi, Yasuhiro; Nakanishi, Kyoko; Takiguchi, Chikako; Oka, Naomi; Inomata, Norio
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 5 p. 623 - 635
反应条件
dimethylaluminum chloride in hexane; toluene T=20°C; Friedel-Crafts reaction; P=22502.3 Torr; 3 h;
参考文献
Nemoto, Koji; Onozawa, Satoru; Egusa, Naoki; Morohashi, Naoya; Hattori, Tetsutaro
Tetrahedron Letters, 2009 , vol. 50, # 31 p. 4512 - 4514
反应条件
1.1: t-BuOK; 18-crown-6 / diethyl ether / 0 °C 1.2: 78 percent / diethyl ether / 1 h / 20 °C 2.1: 79 percent / 1 N aq. NaOH / methanol / 6 h / Heating View Scheme
参考文献
Mizuno, Akira; Ogata, Atsuto; Kamei, Tomoe; Shibata, Makoto; Shimamoto, Tetsuo; Hayashi, Yasuhiro; Nakanishi, Kyoko; Takiguchi, Chikako; Oka, Naomi; Inomata, Norio
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 5 p. 623 - 635
反应条件
sodium hydroxide; silver nitrate
参考文献
Mai; Artico, Marino; Esposito; Ragno; Sbardella; Massa
Farmaco, 2003 , vol. 58, # 3 p. 231 - 241
