1-苯基-3-吡啶-4-基丙烷-1-酮合成路线 (共 2 条)
反应条件
[Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; potassium tert-butylate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,1-dimethylpropan-1-ol
T=120°C; 16 h; Inert atmosphereSchlenk technique;
参考文献
Yan, Feng-Xia; Zhang, Min; Wang, Xiao-Ting; Xie, Feng; Chen, Meng-Meng; Jiang, Huanfeng
Tetrahedron, 2014 , vol. 70, # 6 p. 1193 - 1198
反应条件
1: in tetrahydrofuran
T=-78 - 4°C; 2 h;
2: With water; ammonium chloride in tetrahydrofuran
T=20°C; pH=8.8;
参考文献
ASTRAZENECA AB
Patent: WO2007/18466 A1, 2007 ;
Location in patent: Page/Page column 10; 22; 23 ;
WO 2007/018466 A1