8-[[(9H-芴-9-基甲氧基)羰基]氨基]-1,4-二噁螺[4.5]癸烷-8-羧酸合成路线 （共 4 条）
反应条件
hydrogenchloride in acetone T=20°C; 4 h;
参考文献
Koppitz, Marcus; Reinhardt, Gabriele; Van Lingen, Anneke
Tetrahedron Letters, 2005 , vol. 46, # 6 p. 911 - 914
反应条件
1: 8-amino-1,4-dioxaspiro[4,5]decane-8-carboxylic acid With hydrogenchloride in water
pH=10;
2: 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]-2,5-pyrrolidinedione in water; acetonitrile
T=20°C;
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/119941 A1, 2012 ;
Location in patent: Page/Page column 109-110 ;
WO 2012/119941 A1
反应条件
1.1: water / ethanol / 12 h / 50 °C
2.1: sodium hydroxide; ethanol / Reflux
3.1: hydrogenchloride / water / pH 10
3.2: 20 °C
View Scheme
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/119941 A1, 2012 ;
WO 2012/119941 A1
反应条件
1.1: sodium hydroxide; ethanol / Reflux
2.1: hydrogenchloride / water / pH 10
2.2: 20 °C
View Scheme
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/119941 A1, 2012 ;
WO 2012/119941 A1
