1-羟基-3-甲基丁烷-2-酮合成路线 （共 13 条）
反应条件
triethylamine; 3-ethylbenzothiazolium bromide in ethanol
T=60°C; 72 h; Inert atmosphere;
参考文献
Gangjee, Aleem; Jain, Hiteshkumar D.; Queener, Sherry F.; Kisliuk, Roy L.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 15 p. 4589 - 4600
反应条件
sodium hydrogencarbonate in methanol; water
1 h; Heating;
参考文献
Waszkuc, Wieslaw; Janecki, Tomasz; Bodalski, Ryszard
Synthesis, 1984 , # 12 p. 1025 - 1027
反应条件
Pseudomonas putida ML 2; wild type strain in phosphate buffer
T=4°C; Dehydrogenation; enantiomeric separation; hydrogenation; pH=7.5; 24 h; Enzymatic reaction; Title compound not separated from byproducts;
参考文献
Boyd, Derek R.; Clarke, David; Cleij, Marcel C.; Hamilton, John T.G.; Sheldrake, Gary N.
Monatshefte fur Chemie, 2000 , vol. 131, # 6 p. 673 - 685
反应条件
sodium acetate; acetic acid in ethylene glycol dimethyl ether
参考文献
Thorpe,J.W.; Warkentin,J.
Canadian Journal of Chemistry, 1973 , vol. 51, p. 927 - 935
反应条件
1: 72 percent / 4-methylmorpholine 4-oxide dihydrate, osmium tetroxide / acetone; 2-methyl-propan-2-ol / 72 h / Ambient temperature
2: 70 percent / NaHCO3 / H2O; methanol / 1 h / Heating
View Scheme
参考文献
Waszkuc, Wieslaw; Janecki, Tomasz; Bodalski, Ryszard
Synthesis, 1984 , # 12 p. 1025 - 1027
反应条件
1: Br2 / methanol
2: HCO2K / methanol / Heating
View Scheme
参考文献
Guette,J.-P.; Spassky,N.
Bulletin de la Societe Chimique de France, 1972 , p. 4217 - 4224
反应条件
sodium acetate; acetic acid in ethylene glycol dimethyl ether
参考文献
Thorpe,J.W.; Warkentin,J.
Canadian Journal of Chemistry, 1973 , vol. 51, p. 927 - 935
反应条件
hydrogenchloride; mercury dichloride in ethanol
参考文献
Sperna Weiland,J.H.; Arens,J.F.
Recueil des Travaux Chimiques des Pays-Bas, 1960 , vol. 79, p. 1293 - 1300
反应条件
N(Et)4ClO4 in N,N-dimethyl-formamide
T=20°C; glassy carbon electrode;
参考文献
Chiarotto, Isabella; Feroci, Marta; Giomini, Claudio; Inesi, Achille
Bulletin de la Societe Chimique de France, 1996 , vol. 133, # 2 p. 167 - 175
反应条件
diethyl ether
anschliessendes Behandeln mit wss.Schwefelsaeure;
参考文献
Pfeil; Barth
Justus Liebigs Annalen der Chemie, 1955 , vol. 593, p. 81,87
