(2-氧代庚基)膦酸二甲酯合成路线 （共 14 条）
参考文献
K.K. Ueno Seiyaku Oyo Kenkyujo
Patent: US5117042 A1, 1992 ;
反应条件
sodium hydride in ethylene glycol dimethyl ether T=0 - 20°C; Yield given;
参考文献
Chen, Lian-yong; Ghosez, Leon
Tetrahedron: Asymmetry, 1991 , vol. 2, # 12 p. 1181 - 1184
反应条件
1: (2-oxoheptyl)phosphonic acid dimethyl ester With N-ethyl-N,N-diisopropylamine; lithium chloride in acetonitrile
T=20°C; Horner-Wadsworth-Emmons reaction;
2: 2,4-dimethyl-3-methoxymethoxy-5-oxo-2,5-dihydrothiophene-2-carbaldehyde in acetonitrile
T=20°C; 2 h;
参考文献
Kim, Pilho; Barry III, Clifton E.; Dowd, Cynthia S.
Tetrahedron Letters, 2006 , vol. 47, # 20 p. 3447 - 3451
反应条件
n-butyllithium; sodium chloride in tetrahydrofuran; hexane; ethyl acetate; benzene
参考文献
Ono Pharmaceutical Company
Patent: US4069387 A1, 1978 ;
