1-(乙氧羰基)环丙烷羧酸合成路线 （共 9 条）
反应条件
hydrogen fluoride in dichloromethane
参考文献
BASF Aktiengesellschaft
Patent: US5371268 A1, 1994 ;
反应条件
sulfur(IV) fluoride T=60°C; Substitution; 21 h; Title compound not separated from byproducts;
参考文献
Hell; Finta; Dmowski; Faigl; Pustovit; Toke; Harmat
Journal of Fluorine Chemistry, 2000 , vol. 104, # 2 p. 297 - 301
反应条件
diphenyl phosphoryl azide; triethylamine T=20°C; 5 h; Heating / reflux;
参考文献
Wyeth
Patent: US2008/45556 A1, 2008 ;
Location in patent: Page/Page column 21 ;
反应条件
1-hydroxy-2(1H)-pyridinethione; dicyclohexyl-carbodiimide 1.) CHCl3, room temperature, 6 h, 2.) CHCl3, room temperature, irradiation; Yield given. Multistep reaction;
参考文献
Hell, Zoltan; Toke, Laszlo
Synthetic Communications, 1996 , vol. 26, # 11 p. 2127 - 2133
反应条件
1: tert-butyl alcohol With diisopropyl-carbodiimide; copper(l) chloride T=20°C; 96 h; Darkness; 2: 1-Ethoxycarbonylcyclopropanecarboxylic acid in dichloromethane 3 h; Reflux;
参考文献
EP2471792 A1, ;
Page/Page column 66 ;
反应条件
1: With sodium hydroxide; water in ethanol
16 h;
2: With hydrogenchloride in water
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2005/79812 A1, 2005 ;
Location in patent: Page/Page column 45-46 ;
反应条件
1: potassium carbonate; tetrabutylammomium bromide / |Inert atmosphere; |Schlenk technique
2: potassium hydroxide / ethanol; water / 5 h / 20 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Li, Wanfang; Tao, Xiaoming; Ma, Xin; Fan, Weizheng; Li, Xiaoming; Zhao, Mengmeng; Xie, Xiaomin; Zhang, Zhaoguo
Chemistry - A European Journal, 2012 , vol. 18, # 51 p. 16531 - 16539
反应条件
1: With triethylamine; isobutyl chloroformate in tetrahydrofuran
T=-10 - 0°C; 1 h;
2: With sodium tetrahydroborate; water in tetrahydrofuran
T=0°C; 1 h;
参考文献
SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin; YANG, Heping; YU, Yajun
Patent: WO2013/91502 A1, 2013 ;
Location in patent: Page/Page column 43 ;
反应条件
bromine; mercury(II) oxide in tetrachloromethane
3 h; HeatingIrradiation;
参考文献
Barnier, Jean-Pierre; Rousseau, Gerard; Conia, Jean-Marie
Synthesis, 1983 , # 11 p. 915 - 916
