4-[[(4-甲基苯基)磺酰基]氨基]苯甲酸合成路线 （共 9 条）
反应条件
sulfuric acid 1) 35 deg C, 1 h, 2) 25 deg C, 3 h;
参考文献
Markov, V. I.; Dmitrikova, L. V.; Dubina, V. L.; Burmistrov, K. S.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, # 11 p. 2222 - 2223
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 11 p. 2463 - 2464
反应条件
potassium hydroxide in water 1 h; Heating;
参考文献
Hellwinkel, Dieter; Lenz, Ruediger
Chemische Berichte, 1985 , vol. 118, # 1 p. 66 - 85
反应条件
sulfuric acid 1) 35 deg C, 1 h, 2) 25 deg C, 3 h;
参考文献
Markov, V. I.; Dmitrikova, L. V.; Dubina, V. L.; Burmistrov, K. S.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, # 11 p. 2222 - 2223
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 11 p. 2463 - 2464
反应条件
sodium carbonate in water
T=25°C; pH=8; 2 h;
参考文献
Mustafa, Ghulam; Khan, Islam Ullah; Ashraf, Muhammad; Afzal, Iftikhar; Shahzad, Sohail Anjum; Shafiq, Muhammad
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 8 p. 2535 - 2539
反应条件
1: With sodium hydroxide in water; acetone
2 h;
2: With hydrogenchloride in water
pH=2;
参考文献
Zhang, Jiankang; Shen, Luqing; Wang, Jincheng; Luo, Peihua; Hu, Yongzhou
Medicinal Chemistry, 2014 , vol. 10, # 1 p. 38 - 45
反应条件
1.1: pyridine / 0 - 20 °C / |Inert atmosphere
2.1: sodium hydroxide / acetone; water / 2 h
2.2: pH 2
View Scheme
参考文献
Zhang, Jiankang; Shen, Luqing; Wang, Jincheng; Luo, Peihua; Hu, Yongzhou
Medicinal Chemistry, 2014 , vol. 10, # 1 p. 38 - 45
反应条件
1.1: pyridine / 0 - 20 °C / |Inert atmosphere
2.1: sodium hydroxide / acetone; water / 2 h
2.2: pH 2
View Scheme
参考文献
Zhang, Jiankang; Shen, Luqing; Wang, Jincheng; Luo, Peihua; Hu, Yongzhou
Medicinal Chemistry, 2014 , vol. 10, # 1 p. 38 - 45
反应条件
pyridine; thionyl chloride; benzene
参考文献
Zhang, Jiankang; Shen, Luqing; Wang, Jincheng; Luo, Peihua; Hu, Yongzhou
Medicinal Chemistry, 2014 , vol. 10, # 1 p. 38 - 45
反应条件
1: 4-(toluene-4-sulfonylamino)-benzoic acid With sodium hydride in N,N-dimethyl-formamide
T=25°C; 0.666667 h;
2: ethyl iodide in N,N-dimethyl-formamide
T=25°C; 3 h;
参考文献
Mustafa, Ghulam; Khan, Islam Ullah; Ashraf, Muhammad; Afzal, Iftikhar; Shahzad, Sohail Anjum; Shafiq, Muhammad
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 8 p. 2535 - 2539
