(8As)-六氢吡咯并[1,2-a]吡嗪-1,4-二酮合成路线 （共 27 条）
反应条件
1: 58 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, HOBT monohydrate, Et3N / 24 h / Ambient temperature 2: 100 percent / 1 h / Ambient temperature 3: 65 percent / Et3N / methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 16 p. 2311 - 2320
反应条件
1: 57 percent / H2NNH2*H2O / ethanol / 2 h / Heating 2: 80 percent / Na, liq. NH3 / tetrahydrofuran / 0.25 h / -60 °C View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 16 p. 2297 - 2311
反应条件
1: NMM, iso-butyl chloroformate / tetrahydrofuran; dimethylformamide / -40 °C 2: H2NNH2*H2O / ethanol / Heating 3: ethanol / 1.5 h / Heating 4: Na, NH3 liq. / -68 °C View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 1 p. 85 - 88
反应条件
1: 92.5 percent / SOCl2 2: 77.2 percent / Et3N / benzene / Ambient temperature 3: 78.2 percent / NH3 / ethanol / Ambient temperature View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 18, # 12 p. 811 - 815
Khimiko-Farmatsevticheskii Zhurnal, , vol. 18, # 12 p. 1445 - 1448
反应条件
1: 77.2 percent / Et3N / benzene / Ambient temperature 2: 78.2 percent / NH3 / ethanol / Ambient temperature View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 18, # 12 p. 811 - 815
Khimiko-Farmatsevticheskii Zhurnal, , vol. 18, # 12 p. 1445 - 1448
反应条件
hydrazine hydrate 1.) CHCl3, reflux, 4 h, 2.) CHCl3, EtOH, a) RT, 12 h, b) reflux, 24 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 10 p. 1814 - 1820
反应条件
methanol; zinc Heating;
参考文献
Tetrahedron Letters, , vol. 29, # 21 p. 2539 - 2542
反应条件
1: palladium; acetic acid; aqueous methanol / Hydrogenation 2: HCl 3: 105 °C / 0 Torr View Scheme
参考文献
Journal of the Chemical Society, , p. 3642,3646
反应条件
1: aqueous NaOH; acetone 2: palladium; acetic acid; aqueous methanol / Hydrogenation 3: HCl 4: 105 °C / 0 Torr View Scheme
参考文献
Journal of the Chemical Society, , p. 3642,3646
反应条件
T=105°C; P=0.001 Torr;
参考文献
Journal of the Chemical Society, , p. 3642,3646
