4,5-二碘-1-甲基-1H-咪唑合成路线 （共 6 条）
反应条件
1: 4,5-diiodo-1H-imidazole With potassium tert-butylate in tetrahydrofuran T=0°C; 1 h; Inert atmosphere; 2: methyl iodide in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Kunz, Peter C.; Thiel, Indre; Noffke, Anna Louisa; Reiss, Guido J.; Mohr, Fabian; Spingler, Bernhard
Journal of Organometallic Chemistry, 2012 , vol. 697, # 1 p. 33 - 40
反应条件
sulfuric acid; iodine; iodic acid; acetic acid in tetrachloromethane; water 12 h; Heating;
参考文献
Borai, M. El; Moustafa, A. H.; Anwar, M.; Hay, F. I. Abdel
Polish Journal of Chemistry, 1981 , vol. 55, # 7/8 p. 1659 - 1665
反应条件
1: 4,5-diiodo-1-methyl-1H-imidazole With ethylmagnesium bromide in diethyl ether; dichloromethane T=20°C; Inert atmosphere; 2: N-methyl-N-formyl-aniline in diethyl ether; dichloromethane T=20°C; 16 h; Inert atmosphere;
参考文献
Koswatta, Panduka B.; Sivappa, Rasapalli; Dias, H. V. Rasika; Lovely, Carl J.
Synthesis, 2009 , # 17 p. 2970 - 2982
反应条件
1: With ethylmagnesium bromide in tetrahydrofuran; diethyl ether T=0°C; 1 h; Inert atmosphere; 2: With water in tetrahydrofuran; diethyl ether T=20°C; Inert atmosphere;
参考文献
Kunz, Peter C.; Thiel, Indre; Noffke, Anna Louisa; Reiss, Guido J.; Mohr, Fabian; Spingler, Bernhard
Journal of Organometallic Chemistry, 2012 , vol. 697, # 1 p. 33 - 40
反应条件
ethylmagnesium bromide; lithium chloride 1.) THF, -20 deg C, 30 min; 2.) THF, -20 deg C, 15 min; 3.) THF, -20 deg C to 0 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Benhida, Rachid; Lezama, Ruth; Fourrey, Jean-Louis
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 5963 - 5964
反应条件
cesium fluoride; N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine; palladium diacetate in 1,4-dioxane; N,N-dimethyl-formamide
T=80°C; Suzuki coupling; 12 h;
参考文献
Dobler, Markus R.
Tetrahedron Letters, 2003 , vol. 44, # 38 p. 7115 - 7117
