(S)-3-氨基-3-苯基丙酸甲酯合成路线 （共 51 条）
反应条件
1: With Ru(OAc)2[(R)-dm-segphos]; hydrogen; ammonium salicylate in methanol T=85°C; P=22502.3 Torr; 7 h; Autoclave; 2: With sodium carbonate in water; ethyl acetate 0.5 h; optical yield given as percent eeenantioselective reaction;
参考文献
Matsumura, Kazuhiko; Zhang, Xiaoyong; Hori, Kiyoto; Murayama, Toshiyuki; Ohmiya, Tadamasa; Shimizu, Hideo; Saito, Takao; Sayo, Noboru
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1130 - 1137
反应条件
[{Rh(μ-Cl)(1,5-cyclooctadiene)}2]; [1'-P(4-CF3Ph)2-2'-(R)-CH(Me)-P(t-Bu)2]ferrocene; hydrogen in 2,2,2-trifluoroethanol T=50°C; P=5171.48 Torr; 6 h;
参考文献
Hsiao, Yi; Rivera, Nelo R.; Rosner, Thorsten; Krska, Shane W.; Njolito, Eugenia; Wang, Fang; Sun, Yongkui; Armstrong III, Joseph D.; Grabowski, Edward J. J.; Tillyer, Richard D.; Spindler, Felix; Malan, Christophe
Journal of the American Chemical Society, 2004 , vol. 126, # 32 p. 9918 - 9919
反应条件
thionyl chloride Heating;
参考文献
Davies, Stephen G.; Garrido, Narciso M.; Ichihara, Osamu; Walters, Iain A. S.
Journal of the Chemical Society, Chemical Communications, 1993 , # 14 p. 1153 - 1155
反应条件
hydrogen; palladium on activated charcoal in methanol T=25°C; Catalytic hydrogenation; P=760 Torr; 2.5 h;
参考文献
Kuroki, Yoshichika; Ishihara, Kazuaki; Hanaki, Naoyuki; Ohara, Suguru; Yamamoto, Hisashi
Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 5 p. 1221 - 1230
反应条件
hydrogen; chloroacetic acid; Ru(OCOCH3)2((R)-H8-binap) in methanol T=50°C; P=22502.3 Torr; 88 h; Product distribution / selectivity;
参考文献
Takasago International Corporation
Patent: EP1386901 A1, 2004 ;
Location in patent: Page 13-14 ;
反应条件
1: With hydrogenchloride in 1,4-dioxane Reflux; 2: With sodium hydrogencarbonate in 1,4-dioxane; methanol; water T=20°C;
参考文献
TEXAS HEART INSTITUTE; BIEDIGER, Ronald, J.; GUNDLACH, IV, C., William; MARKET, Robert, V.; SAVAGE, Michael, M.; VANDERSLICE, Peter
Patent: WO2012/68251 A2, 2012 ;
Location in patent: Page/Page column 56 ;
反应条件
1: Ti-(S)-BINOL-4-tert-butylcatechol / toluene / 24 h / -78 °C 2: Zn; H2SO4 / methanol / 2 h / 60 °C 3: hydrogen / Pd/C / methanol / 16 h / 20 °C View Scheme
参考文献
Murahashi, Shun-Ichi; Imada, Yasushi; Kawakami, Toru; Harada, Kazuhito; Yonemushi, Yoshiharu; Tomita, Naomi
Journal of the American Chemical Society, 2002 , vol. 124, # 12 p. 2888 - 2889
反应条件
1: Zn; H2SO4 / methanol / 2 h / 60 °C 2: hydrogen / Pd/C / methanol / 16 h / 20 °C View Scheme
参考文献
Murahashi, Shun-Ichi; Imada, Yasushi; Kawakami, Toru; Harada, Kazuhito; Yonemushi, Yoshiharu; Tomita, Naomi
Journal of the American Chemical Society, 2002 , vol. 124, # 12 p. 2888 - 2889
反应条件
1.1: Et3N / tetrahydrofuran / 12 h / 50 °C 2.1: O3 / CH2Cl2 / -78 °C 2.2: dimethyl sulfide / CH2Cl2 / 12 h / -78 - 20 °C 3.1: NaClO2; aq. NaH2PO4 / 2-methyl-propan-2-ol; various solvent(s) / 20 °C 4.1: NaHCO3 / dimethylformamide / 12 h / 20 °C 5.1: H2 / Pd(OH)2/C / methanol 6.1: TFA / CH2Cl2 View Scheme
参考文献
Okamoto; Teng; Fujii; Takayama; Sato
Journal of the American Chemical Society, 2001 , vol. 123, # 15 p. 3462 - 3471
反应条件
1: H2 / Pd(OH)2/C / methanol 2: TFA / CH2Cl2 View Scheme
参考文献
Okamoto; Teng; Fujii; Takayama; Sato
Journal of the American Chemical Society, 2001 , vol. 123, # 15 p. 3462 - 3471
