(S)-3-氨基-3-苯基丙酸甲酯合成路线 （共 51 条）
反应条件
1: (R,R)-2,6-bis(2-isopropylphenyl)-3,5-dimethylphenyl 3-(2-methoxyphenyl)amino-3-phenylpropionate With tetra(n-butyl)ammonium hydroxide in tetrahydrofuran T=0°C; Saponification; 2: TMSCH2N2 in methanol T=20°C; Methylation; 3: With (NH4)2S2O8; silver nitrate in tetrahydrofuran; water; acetonitrile T=60°C; Oxidative cleavage; Further stages. Title compound not separated from byproducts.;
参考文献
Saito, Susumu; Hatanaka, Keiko; Yamamoto, Hisashi
Organic Letters, 2000 , vol. 2, # 13 p. 1891 - 1894
反应条件
1: With ammonium cerium(IV) nitrate in water; acetonitrile T=20°C; 17 h; 2: With hydrogenchloride in methanol T=60°C; 2 h;
参考文献
Podlech, Joachim
Synthetic Communications, 2000 , vol. 30, # 10 p. 1779 - 1786
反应条件
ammonium cerium (IV) nitrate; water in acetonitrile T=0 - 20°C; optical yield given as percent ee;
参考文献
Zheng, Hong-Jie; Chen, Wen-Bing; Wu, Zhi-Jun; Deng, Jin-Gen; Lin, Wen-Qing; Yuan, Wei-Cheng; Zhang, Xiao-Mei
Chemistry - A European Journal, 2008 , vol. 14, # 32 p. 9864 - 9867
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Kim, Ronald M.; Chang, Jiang; Chapman, Kevin T.; Mills, Sander G.
Patent: US2002/193407 A1, 2002 ;
反应条件
1: 100 percent / trifluoroacetic acid 2: 95 percent / SOCl2 / Heating View Scheme
参考文献
Perros, Manoussos; Price, David Anthony; Stammen, Blanda Luzia Christa; Wood, Anthony
Patent: US2002/13337 A1, 2002 ;
反应条件
palladium hydroxide on carbon; hydrogen in methanol P=3102.97 Torr; 144 h;
参考文献
Abrunhosa-Thomas, Isabelle; Plas, Aurelie; Vogrig, Alexandre; Kandepedu, Nishanth; Chalard, Pierre; Troin, Yves
Journal of Organic Chemistry, 2013 , vol. 78, # 6 p. 2511 - 2526
反应条件
1: (R,R)-2,6-bis(2-isopropylphenyl)-3,5-dimethylphenyl 3-(2,4-dimethoxyphenyl)amino-3-phenylpropionate With tetra(n-butyl)ammonium hydroxide in tetrahydrofuran T=0°C; Saponification; 2: TMSCH2N2 in methanol T=20°C; Methylation; 3: With ammonium cerium(IV) nitrate in water; acetonitrile T=0°C; Oxidative cleavage; Further stages. Title compound not separated from byproducts.;
参考文献
Saito, Susumu; Hatanaka, Keiko; Yamamoto, Hisashi
Organic Letters, 2000 , vol. 2, # 13 p. 1891 - 1894
反应条件
in methanol T=20°C; Inert atmosphereRefluxLarge scale;
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
反应条件
1: 85 percent / 1.) HCl, 2.) NaOH View Scheme
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
反应条件
1: ammonium acetate / butan-1-ol 2: 85 percent / 1.) HCl, 2.) NaOH View Scheme
参考文献
Kuehne, Paul; Linden, Anthony; Hesse, Manfred
Helvetica Chimica Acta, 1996 , vol. 79, # 4 p. 1085 - 1094
