(S)-3-氨基-3-苯基丙酸甲酯合成路线 （共 51 条）
反应条件
potassium dihydrogenphosphate; water; Amano Lipase PS T=30°C; pH=8.2; 15.5 h; Resolution of racemate; Product distribution / selectivity;
参考文献
Ube Industries, Ltd.
Patent: EP1621529 A1, 2006 ;
Location in patent: Page/Page column 25-26 ;
反应条件
(NH4)2S2O8; silver nitrate in tetrahydrofuran; water; acetonitrile T=60°C; 4 h; Title compound not separated from byproducts;
参考文献
Saito, Susumu; Hatanaka, Keiko; Yamamoto, Hisashi
Tetrahedron, 2001 , vol. 57, # 5 p. 875 - 887
反应条件
ammonium cerium(IV) nitrate in water; acetonitrile T=0°C; 0.666667 h; Title compound not separated from byproducts;
参考文献
Saito, Susumu; Hatanaka, Keiko; Yamamoto, Hisashi
Tetrahedron, 2001 , vol. 57, # 5 p. 875 - 887
反应条件
1: 58 percent / (S)-BLA / CH2Cl2; toluene / 20 h / -78 °C 2: 99.5 percent / conc. H2SO4 / 2 h / Heating 3: 95 percent / H2 / Pd/C / methanol / 2.5 h / 25 °C / 760 Torr View Scheme
参考文献
Kuroki, Yoshichika; Ishihara, Kazuaki; Hanaki, Naoyuki; Ohara, Suguru; Yamamoto, Hisashi
Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 5 p. 1221 - 1230
反应条件
1: 99.5 percent / conc. H2SO4 / 2 h / Heating 2: 95 percent / H2 / Pd/C / methanol / 2.5 h / 25 °C / 760 Torr View Scheme
参考文献
Kuroki, Yoshichika; Ishihara, Kazuaki; Hanaki, Naoyuki; Ohara, Suguru; Yamamoto, Hisashi
Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 5 p. 1221 - 1230
反应条件
Carica papaya lipase in hexane T=45°C; Resolution of racemateEnzymatic reaction;
参考文献
You, Pengyong; Qiu, Jian; Su, Erzheng; Wei, Dongzhi
European Journal of Organic Chemistry, 2013 , # 3 p. 557 - 565
反应条件
1: 1) LDA / 2) -78 deg C 2: 73 percent / CF3CO2H / methanol / 2 h / 0 °C View Scheme
参考文献
Davis, Franklin A.; Reddy, R. Thimma; Reddy, Rajarathnam E.
Journal of Organic Chemistry, 1992 , vol. 57, # 24 p. 6387 - 6389
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / |Inert atmosphere 1.2: 2 h / -78 °C / |Inert atmosphere 2.1: hydrogen; palladium hydroxide on carbon / methanol / 144 h / 3102.97 Torr View Scheme
参考文献
Abrunhosa-Thomas, Isabelle; Plas, Aurelie; Vogrig, Alexandre; Kandepedu, Nishanth; Chalard, Pierre; Troin, Yves
Journal of Organic Chemistry, 2013 , vol. 78, # 6 p. 2511 - 2526
反应条件
Pseudomonas cepacia lipase immobilized on diatomite; water in 1,4-dioxane T=45°C; 102.5 h; Enzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Rodriguez-Mata, Maria; Garcia-Urdiales, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 2-3 p. 395 - 406
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: Et2Zn / tetrahydrofuran; hexane / 27 h / -78 °C 2.1: 99 percent / n-Bu4NOH / tetrahydrofuran / 1.5 h / 0 °C 3.1: 99 percent / methanol / 20 °C 4.1: AgNO3; (NH4)2S2O8 / H2O; acetonitrile; tetrahydrofuran / 4 h / 60 °C View Scheme
参考文献
Saito, Susumu; Hatanaka, Keiko; Yamamoto, Hisashi
Tetrahedron, 2001 , vol. 57, # 5 p. 875 - 887
