(S)-3-氨基-3-苯基丙酸甲酯合成路线 （共 51 条）
反应条件
Candida antarctica Lipase type B in tert-butyl methyl ether T=45°C; 27 h; Inert atmosphereEnzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Rodriguez-Mata, Maria; Garcia-Urdiales, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 2-3 p. 395 - 406
反应条件
hydrogen; palladium on activated charcoal 1.) AcOH; 2.) CH3OH; Yield given. Multistep reaction;
参考文献
Escalante, Jaime; Juaristi, Eusebio
Tetrahedron Letters, 1995 , vol. 36, # 25 p. 4397 - 4400
反应条件
1: -78 °C 2: 84 percent / H2, acetic acid / Pd/C / 5320 Torr 3: 100 percent / trifluoroacetic acid 4: 95 percent / SOCl2 / Heating View Scheme
参考文献
Davies, Stephen G.; Garrido, Narciso M.; Ichihara, Osamu; Walters, Iain A. S.
Journal of the Chemical Society, Chemical Communications, 1993 , # 14 p. 1153 - 1155
反应条件
1: 84 percent / H2, acetic acid / Pd/C / 5320 Torr 2: 100 percent / trifluoroacetic acid 3: 95 percent / SOCl2 / Heating View Scheme
参考文献
Davies, Stephen G.; Garrido, Narciso M.; Ichihara, Osamu; Walters, Iain A. S.
Journal of the Chemical Society, Chemical Communications, 1993 , # 14 p. 1153 - 1155
反应条件
1: (S)-(2-(bis(3,3-dimethylphenyl)(hydroxy)methyl)pyrrolidin-1-yl)(pyridin-2-yl)methanone; trichlorosilane / chloroform / 48 h / -30 °C 2: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C View Scheme
参考文献
Zheng, Hong-Jie; Chen, Wen-Bing; Wu, Zhi-Jun; Deng, Jin-Gen; Lin, Wen-Qing; Yuan, Wei-Cheng; Zhang, Xiao-Mei
Chemistry - A European Journal, 2008 , vol. 14, # 32 p. 9864 - 9867
反应条件
1: sodium hydride / toluene / Reflux 2: toluene-4-sulfonic acid / methanol / Reflux 3: (S)-(2-(bis(3,3-dimethylphenyl)(hydroxy)methyl)pyrrolidin-1-yl)(pyridin-2-yl)methanone; trichlorosilane / chloroform / 48 h / -30 °C 4: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C View Scheme
参考文献
Zheng, Hong-Jie; Chen, Wen-Bing; Wu, Zhi-Jun; Deng, Jin-Gen; Lin, Wen-Qing; Yuan, Wei-Cheng; Zhang, Xiao-Mei
Chemistry - A European Journal, 2008 , vol. 14, # 32 p. 9864 - 9867
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
反应条件
hydrogenchloride 1 h; Heating; Yield given;
参考文献
Kuehne, Paul; Linden, Anthony; Hesse, Manfred
Helvetica Chimica Acta, 1996 , vol. 79, # 4 p. 1085 - 1094
反应条件
1: 90 percent / aq. NaHCO3 2: 75 percent / diisobutylaluminium hydride / CH2Cl2 / -78 °C 3: 75 percent / Na(AcO)3BH / CH2Cl2 View Scheme
参考文献
Price, David A.; Gayton, Simon; Selby, Matthew D.; Ahman, Jens; Haycock-Lewandowski, Sarah; Stammen, Blanda L.; Warren, Andrew
Tetrahedron Letters, 2005 , vol. 46, # 30 p. 5005 - 5007
反应条件
1: sodium carbonate / dichloromethane; water / 16 h / 20 °C 2: sodium hydroxide / methanol; water / 16 h / 20 °C View Scheme
参考文献
Abrunhosa-Thomas, Isabelle; Plas, Aurelie; Kandepedu, Nishanth; Chalard, Pierre; Troin, Yves
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 486 - 495
