(S)-3-氨基-3-苯基丙酸甲酯合成路线 （共 51 条）
反应条件
hydrogenchloride; sodium hydroxide 16 h; Ambient temperature;
参考文献
Wasserman, Harry H.; Berger, Gregory D.
Tetrahedron, 1983 , vol. 39, # 15 p. 2459 - 2464
反应条件
triethylamine in chloroform T=0 - 20°C; optical yield given as percent ee;
参考文献
Chemistry - A European Journal, , vol. 14, # 32 p. 9864 - 9867
反应条件
triethylamine in chloroform T=0 - 20°C; optical yield given as percent ee;
参考文献
Zheng, Hong-Jie; Chen, Wen-Bing; Wu, Zhi-Jun; Deng, Jin-Gen; Lin, Wen-Qing; Yuan, Wei-Cheng; Zhang, Xiao-Mei
Chemistry - A European Journal, 2008 , vol. 14, # 32 p. 9864 - 9867
反应条件
1: 90 percent / aq. NaHCO3 2: 75 percent / diisobutylaluminium hydride / CH2Cl2 / -78 °C 3: 75 percent / Na(AcO)3BH / CH2Cl2 4: 95 percent / CF3CO2H / CH2Cl2 5: 49 percent / polimer bound carbodiimide / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Price, David A.; Gayton, Simon; Selby, Matthew D.; Ahman, Jens; Haycock-Lewandowski, Sarah; Stammen, Blanda L.; Warren, Andrew
Tetrahedron Letters, 2005 , vol. 46, # 30 p. 5005 - 5007
反应条件
1: 92 mg / Et3N / 1 h / 0 °C 2: 92 percent / aq. LiOH / methanol; tetrahydrofuran / 1 h / 0 - 20 °C View Scheme
参考文献
Synlett, , # 12 p. 2039 - 2040
反应条件
1: 90 percent / aq. NaHCO3 2: 75 percent / diisobutylaluminium hydride / CH2Cl2 / -78 °C View Scheme
参考文献
Price, David A.; Gayton, Simon; Selby, Matthew D.; Ahman, Jens; Haycock-Lewandowski, Sarah; Stammen, Blanda L.; Warren, Andrew
Tetrahedron Letters, 2005 , vol. 46, # 30 p. 5005 - 5007
反应条件
sodium hydrogencarbonate
参考文献
Price, David A.; Gayton, Simon; Selby, Matthew D.; Ahman, Jens; Haycock-Lewandowski, Sarah; Stammen, Blanda L.; Warren, Andrew
Tetrahedron Letters, 2005 , vol. 46, # 30 p. 5005 - 5007
反应条件
sodium carbonate in dichloromethane; water T=20°C; 3 h;
参考文献
Abrunhosa-Thomas, Isabelle; Plas, Aurelie; Kandepedu, Nishanth; Chalard, Pierre; Troin, Yves
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 486 - 495
反应条件
1: 93 percent / 3 h / 125 - 135 °C
2: 31 percent / NaBH3CN / acetic acid / 1 h / 50 °C / before heating 2 h, after heating 23 h room temperature
3: 83 percent / NaOEt / toluene / 5 h
4: 87 percent / hydrogen / Raney Ni / aq. NH3; aq. ethanol / 14 h / 2585.7 Torr
5: 88 percent / NaOH / aq. ethanol / 264 h / 55 °C
6: 68 percent / (+/-)-trans-2-(butylsulfonyl)-3-phenyloxaziridine / CH2Cl2 / 0.67 h
View Scheme
参考文献
Kuehne, Paul; Linden, Anthony; Hesse, Manfred
Helvetica Chimica Acta, 1996 , vol. 79, # 4 p. 1085 - 1094
反应条件
6: 1.) <O>
7: 1.) n-Bu4NF, 2.) aq.AcOH / 1.) THF, 0 deg C
8: 68 percent / diethyl cyanophosphate / dimethylformamide / 0 °C
9: 86 percent / <O>
10: 69 percent / lithium hexamethyldisilazide / tetrahydrofuran / -78 - 0 °C
11: 1.) DDQ, 2.) aq.HCl / 1.) CH2Cl2, H2O
12: 64 percent / trifluoroacetic acid / 2.5 h / Ambient temperature
View Scheme
参考文献
Smith III; Rano; Chida; Sulikowski
Journal of Organic Chemistry, 1990 , vol. 55, # 4 p. 1136 - 1138
