1: 1-(Methylthio)-4-fluorobenzene With n-butyllithium in tetrahydrofuran; hexane T=-50°C; Metallation; 6 h; 2: methyl iodide in tetrahydrofuran; hexane T=20°C; Methylation; 3 h; Title compound not separated from byproducts;
参考文献
Cabiddu; Cadoni; Fattuoni; Melis
Journal of Fluorine Chemistry, 1999 , vol. 98, # 2 p. 97 - 106
1: With bis(acetylacetonate)nickel(II); ((2-hydroxymethyl)phenyl)diphenylphosphine in diethyl ether
4 h;
2: With methanol in diethyl ether
Product distribution / selectivity;
参考文献
THE UNIVERSITY OF TOKYO
Patent: WO2006/85628 A1, 2006 ;
Location in patent: Page/Page column 29 ;
1: 1-(Methylthio)-4-fluorobenzene With n-butyllithium in tetrahydrofuran; hexane
T=-50°C; Metallation; 6 h;
2: methyl iodide in tetrahydrofuran; hexane
T=20°C; Methylation; 3 h; Title compound not separated from byproducts;
参考文献
Cabiddu; Cadoni; Fattuoni; Melis
Journal of Fluorine Chemistry, 1999 , vol. 98, # 2 p. 97 - 106
