反应条件
1.1: NaH / dimethylformamide / 0 °C 1.2: 80 percent / dimethylformamide / 18 h / 160 - 170 °C 2.1: 45 percent / polyphosphoric acid / benzene / 2.5 h / Heating 3.1: 85 percent / H2; AcOH / Pd/C / 12 h / 2585.74 Torr 4.1: 39 percent / TiCl4 / CH2Cl2 / 0 - 20 °C 5.1: 3-tert-butyl-4-hydroxy-5-methylphenyl sulfide; m-CPBA / CH2Cl2 / 16 h / Heating 5.2: 50 percent / aq. NaOH / ethanol / 3 h / 20 °C View Scheme
参考文献
Mewshaw, Richard E.; Zhou, Dahui; Zhou, Ping; Shi, Xiaojie; Hornby, Geoffrey; Spangler, Taylor; Scerni, Rosemary; Smith, Deborah; Schechter, Lee E.; Andree, Terrance H.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3823 - 3842