4-氟苯酚合成路线

参考文献

Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;

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Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1

4548-45-22-氯-5-硝基吡啶+

371-41-54-氟苯酚

31011-26-42-(4-氟-苯氧基)-5-硝基-吡啶

参考文献

Freeman-Cook, Kevin D.; Reiter, Lawrence A.; Noe, Mark C.; Antipas, Amy S.; Danley, Dennis E.; Datta, Kaushik; Downs, James T.; Eisenbeis, Shane; Eskra, James D.; Garmene, David J.; Greer, Elaine M.; Griffiths, Richard J.; Guzman, Roberto; Hardink, Joel R.; Janat, Fouad; Jones, Christopher S.; Martinelli, Gary J.; Mitchell, Peter G.; Laird, Ellen R.; Liras, Jennifer L.; Lopresti-Morrow, Lori L.; Pandit, Jayvardhan; Reilly, Usa D.; Robertson, Donald; Vaughn-Bowser, Marcie L.; Wolf-Gouviea, Lilli A.; Yocum, Sue A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 23 p. 6529 - 6534

371-41-54-氟苯酚

34849-57-52-(2-乙酰基-4-氟苯氧基)乙酸乙酯

参考文献

Nittoli, Thomas; Curran, Kevin; Insaf, Shabana; DiGrandi, Martin; Orlowski, Mark; Chopra, Rajiv; Agarwal, Atul; Howe, Anita Y. M.; Prashad, Amar; Floyd, M. Brawner; Johnson, Bernard; Sutherland, Alan; Wheless, Karen; Feld, Boris; O'Connell, John; Mansour, Tarek S.; Bloom, Jonathan
Journal of Medicinal Chemistry, 2007 , vol. 50, # 9 p. 2108 - 2116

371-41-54-氟苯酚

305805-77-0

参考文献

Luo, Fen-Tair; Ko, Seng-Li; Liu, Lijun; Chen, Hui
Heterocycles, 2000 , vol. 53, # 9 p. 2055 - 2066

371-41-54-氟苯酚

362-47-0

参考文献

Kim, Minyoung; Sharma, Satyasheel; Park, Jihye; Kim, Mirim; Choi, Yeonhee; Jeon, Yukyoung; Kwak, Jong Hwan; Kim, In Su
Tetrahedron, 2013 , vol. 69, # 32 p. 6552 - 6559

698-63-55-硝基糠醛+

371-41-54-氟苯酚

33342-17-55-(4-氟苯基)-呋喃-2-甲醛

参考文献

Brooks; Stewart; Basha; Bhatia; Ratajczyk; Martin; Craig; Kolasa; Bouska; Lanni; Harris; Malo; Carter; Bell
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4768 - 4775

371-41-54-氟苯酚

3169-71-92-(4-氟苯氧基)苯胺盐酸盐

参考文献

Gao, Kai; Yu, Chang-Bin; Li, Wei; Zhou, Yong-Gui; Zhang, Xumu
Chemical Communications, 2011 , vol. 47, # 27 p. 7845 - 7847

371-41-54-氟苯酚+

109384-19-2N-Boc-4-羟基哌啶

333954-85-1

参考文献

PFIZER PRODUCTS INC.
Patent: WO2004/9550 A1, 2004 ;
Location in patent: Page 47 ;
WO 2004/009550 A1

371-41-54-氟苯酚

319-50-6

参考文献

Finger et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 94,95, 97

371-41-54-氟苯酚+

384-67-8一氯二氟苯乙酮

34888-09-01-(二氟甲氧基)-4-氟苯

参考文献

Zhang, Laijun; Zheng, Ji; Hu, Jinbo
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9845 - 9848