N-去甲基阿地唑仑甲磺酸酯合成路线 （共 3 条）
反应条件
potassium iodide in tetrahydrofuran; methanol
18 h; Ambient temperature;
参考文献
Hester Jr.; Rudzik; Von Voigtlander
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 392 - 402
反应条件
1: tetrahydrofuran / 1.58 h / 0 - 20 °C
2: acetic acid / 0.33 h / Heating
3: 61.6 percent / KI / tetrahydrofuran; methanol / 18 h / Ambient temperature
View Scheme
参考文献
Hester Jr.; Rudzik; Von Voigtlander
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 392 - 402
反应条件
humal liver microsomes in methanol; phosphate buffer
T=37°C; N-demethylation; pH=7.5; Enzymatic reaction; Enzyme kinetics;
参考文献
Venkatakrishnan, Karthik; Von Moltke, Lisa L.; Duan, Su Xiang; Fleishaker, Joseph C.; Shader, Richard I.; Greenblatt, David J.
Journal of Pharmacy and Pharmacology, 1998 , vol. 50, # 3 p. 265 - 274
