3-[2-(4-羟基苯基)乙基]苯酚合成路线 （共 12 条）
反应条件
boron tribromide in dichloromethane
T=-78°C; 16 h;
参考文献
Sawada, Hiromi; Okazaki, Miki; Morita, Daichi; Kuroda, Teruo; Matsuno, Kenji; Hashimoto, Yuichi; Miyachi, Hiroyuki
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7444 - 7447
反应条件
1: H2, FeCl3 / PtO2 / aq. ethanol
2: BBr3 / CH2Cl2
View Scheme
参考文献
Huneck,S.
Tetrahedron, 1976 , vol. 32, p. 109 - 113
反应条件
1: (i) HBr, benzene, (ii) P(OEt)3, (iii) /BRN= 606013/, NaOMe, DMF
2: H2, FeCl3 / PtO2 / aq. ethanol
3: BBr3 / CH2Cl2
View Scheme
参考文献
Huneck,S.
Tetrahedron, 1976 , vol. 32, p. 109 - 113
反应条件
1: (i) HBr, benzene, (ii) P(OEt)3, (iii) /BRN= 606013/, NaOMe, DMF
2: H2, FeCl3 / PtO2 / aq. ethanol
3: BBr3 / CH2Cl2
View Scheme
参考文献
Huneck,S.
Tetrahedron, 1976 , vol. 32, p. 109 - 113
反应条件
1: 22 h / 80 °C
2: sodium methylate / N,N-dimethyl-formamide / 4 h / 120 °C
3: palladium 10 on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C
4: boron tribromide / dichloromethane / 16 h / -78 °C
View Scheme
参考文献
Sawada, Hiromi; Okazaki, Miki; Morita, Daichi; Kuroda, Teruo; Matsuno, Kenji; Hashimoto, Yuichi; Miyachi, Hiroyuki
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7444 - 7447
反应条件
1: sodium methylate / N,N-dimethyl-formamide / 4 h / 120 °C
2: palladium 10 on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C
3: boron tribromide / dichloromethane / 16 h / -78 °C
View Scheme
参考文献
Sawada, Hiromi; Okazaki, Miki; Morita, Daichi; Kuroda, Teruo; Matsuno, Kenji; Hashimoto, Yuichi; Miyachi, Hiroyuki
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7444 - 7447
反应条件
1: HCl
2: AcOH, aq. H2SO4 / Heating
3: (i) H2, aq. HCl, Pd-C, (ii) Zn-Hg, aq. HCl
4: Py*HCl / 210 °C
View Scheme
参考文献
Hopkins,B.J.; Perold,G.W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 32 - 36
反应条件
1: AcOH, aq. H2SO4 / Heating
2: (i) H2, aq. HCl, Pd-C, (ii) Zn-Hg, aq. HCl
3: Py*HCl / 210 °C
View Scheme
参考文献
Hopkins,B.J.; Perold,G.W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 32 - 36
反应条件
1: (i) H2, aq. HCl, Pd-C, (ii) Zn-Hg, aq. HCl
2: Py*HCl / 210 °C
View Scheme
参考文献
Hopkins,B.J.; Perold,G.W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 32 - 36
反应条件
1: NaOEt
2: HCl
3: AcOH, aq. H2SO4 / Heating
4: (i) H2, aq. HCl, Pd-C, (ii) Zn-Hg, aq. HCl
5: Py*HCl / 210 °C
View Scheme
参考文献
Hopkins,B.J.; Perold,G.W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 32 - 36
