2-氯-5,6,7,8,9,10-六氢环庚并[B]吲哚-6-羧酰胺合成路线 （共 3 条）
反应条件
ammonia in methanol
T=90°C; 48 h; Inert atmosphere;
参考文献
ELIXIR PHARMACEUTICALS, INC.; CURTIS, Rory; DISTEFANO, Peter
Patent: WO2010/54382 A1, 2010 ;
Location in patent: Page/Page column 58 ;
反应条件
1: 140 °C
2: 2 g / NH3 / methanol / 48 h / 90 °C
View Scheme
参考文献
Napper, Andrew D.; Hixon, Jeffrey; McDonagh, Thomas; Keavey, Kenneth; Pons, Jean-Francois; Barker, Jonathan; Yau, Wei Tsung; Amouzegh, Patricia; Flegg, Adam; Hamelin, Estelle; Thomas, Russell J.; Kates, Michael; Jones, Stephen; Navia, Manuel A.; Saunders, Jeffrey O.; DiStefano, Peter S.; Curtis, Rory
Journal of Medicinal Chemistry, 2005 , vol. 48, # 25 p. 8045 - 8054
反应条件
1: Br2 / CCl4 / 96 h / 20 °C
2: 140 °C
3: 2 g / NH3 / methanol / 48 h / 90 °C
View Scheme
参考文献
Napper, Andrew D.; Hixon, Jeffrey; McDonagh, Thomas; Keavey, Kenneth; Pons, Jean-Francois; Barker, Jonathan; Yau, Wei Tsung; Amouzegh, Patricia; Flegg, Adam; Hamelin, Estelle; Thomas, Russell J.; Kates, Michael; Jones, Stephen; Navia, Manuel A.; Saunders, Jeffrey O.; DiStefano, Peter S.; Curtis, Rory
Journal of Medicinal Chemistry, 2005 , vol. 48, # 25 p. 8045 - 8054
