2-(2-溴乙氧基)-1,3-二甲基苯合成路线 （共 7 条）
反应条件
sodium hydroxide in water
Reflux;
参考文献
ALLERGAN, INC.; EHRING, George R.; GARST, Michael E.; AVEY, JR., Alfred A.; DOLBY, Lloyd J.; ESFANDIARI, Shervin; MACKENZIE, Vivian R.; MARSDEN, Jeremiah A.; MUCHMORE, David C.
Patent: WO2013/101926 A1, 2013 ;
Location in patent: Page/Page column 28 ;
反应条件
sodium hydroxide in ethanol; water
参考文献
Laroche Navarron S.A.
Patent: US4259334 A1, 1981 ;
反应条件
phosphorus tribromide
参考文献
Marona, Henryk; Antkiewicz-Michaluk, Lucyna
Acta Poloniae Pharmaceutica - Drug Research, 1998 , vol. 55, # 6 p. 487 - 498
反应条件
1.1: sodium hydroxide / water / 0.17 h / |Reflux; |Inert atmosphere
1.2: 40 h / |Reflux; |Inert atmosphere; |Glovebox
2.1: triethylamine / dichloromethane / 0.17 h / 0 °C / |Inert atmosphere; |Schlenk technique; |Glovebox
2.2: 3 h / 0 - 20 °C / |Inert atmosphere; |Schlenk technique; |Glovebox
3.1: lithium bromide / acetone / 24 h / 20 °C
View Scheme
参考文献
Cho, Won Seok; Kim, So Han; Kim, Da Jung; Mun, Sang-Deok; Kim, Ran; Go, Min Jeong; Park, Myung Hwan; Kim, Min; Lee, Junseong; Kim, Youngjo
Polyhedron, 2014 , vol. 67, p. 205 - 212
参考文献
Hey; Willey
British Journal of Pharmacology and Chemotherapy, 1954 , vol. 9, p. 471,475
参考文献
Hey; Willey
British Journal of Pharmacology and Chemotherapy, 1954 , vol. 9, p. 471,475
参考文献
Hey; Willey
British Journal of Pharmacology and Chemotherapy, 1954 , vol. 9, p. 471,475
