Multistep reaction;

sodium ethanolate in ethanol

1: 75 percent 2: 96 percent / NMO; water; OsO4 / toluene; 2-methyl-propan-2-ol / 1 h / 20 °C 3: 44 percent / Amano AK / various solvent(s) / 2 h / 20 °C / Enzymatic reaction 4: triethylamine / tetrahydrofuran / 0.5 h / 0 °C 5: potassium carbonate / ethanol / 6 h / 20 °C View Scheme

1: NaOEt / ethanol 2: 1.) NaH, 2.) Red-AlR / 1.) toluene, reflux, 2.) 45 deg C View Scheme

potassium hydroxide

T=180 - 190°C; 2 h;