4-(2-溴乙氧基)苯甲腈合成路线 （共 7 条）
反应条件
1: N,N-dimethyl-formamide / 2 h / 100 °C 2: hydrazine hydrate / ethanol / 1 h / |Reflux View Scheme
参考文献
GLAXOSMITHKLINE LLC; TEMPERO PHARMACEUTICALS, INC.; GHOSH, Shomir; LOBERA, Mercedes; TRUMP, Ryan, Paul; ZHANG, Cunyu
Patent: WO2013/66833 A1, 2013 ;
反应条件
potassium carbonate; sodium iodide in butanone
18 h; RefluxInert atmosphere;
参考文献
Leigh, David A.; Lusby, Paul J.; McBurney, Roy T.; Morelli, Alessandra; Slawin, Alexandra M. Z.; et al.
Journal of the American Chemical Society, 2009 , vol. 131, p. 3762 - 3771
反应条件
1: 4-hydroxy-benzonitrile With potassium carbonate in DMF (N,N-dimethyl-formamide)
1 h;
2: ethylene dibromide in DMF (N,N-dimethyl-formamide)
T=55 - 60°C;
参考文献
ASTRAZENECA AB
Patent: WO2005/123747 A1, 2005 ;
Location in patent: Page/Page column 55-56 ;
WO 2005/123747 A1
参考文献
AstraZeneca AB
Patent: US6559143 B1, 2003 ;
US 6559143 B1
参考文献
Ashley et al.
Journal of the Chemical Society, 1942 , p. 103,107
反应条件
(i) HCl, (ii) H2SO4, EtOH, (iii) NaI, acetone; Multistep reaction;
参考文献
Hoechst
Patent: FR2233989DE2331081 , 19751975 ;
Chem.Abstr., 1975 , vol. 83, # 96548
反应条件
sulfuric acid; sodium hydrogencarbonate in ethanol; water
参考文献
Hoechst Aktiengesellschaft
Patent: US3984459 A1, 1976 ;
