alpha-溴苯基乙酸甲酯合成路线 （共 64 条）
反应条件
1: dichloromethane / 20 °C 2: triethylamine / dichloromethane / 2 h / 20 °C 3: CuSO4‵5H2O / tetrahydrofuran; water View Scheme
参考文献
Kowalkowska, Anna; Jonczyk, Andrzej
Synthetic Communications, 2011 , vol. 41, # 22 p. 3308 - 3317
反应条件
1.1: dichloromethane / 20 °C 2.1: triethylamine / dichloromethane / 2 h / 20 °C 2.2: 2 h / Reflux View Scheme
参考文献
Kowalkowska, Anna; Jonczyk, Andrzej
Synthetic Communications, 2011 , vol. 41, # 22 p. 3308 - 3317
反应条件
1: ethyldiisopropylamine / acetonitrile / 4 h / 20 °C 2: NaOH / methanol; H2O / 8 h / Heating View Scheme
参考文献
Charton, Julie; Girault-Mizzi, Sophie; Debreu-Fontaine, Marie-Ange; Foufelle, Fabienne; Hainault, Isabelle; Bizot-Espiard, Jean-Guy; Caignard, Daniel-Henri; Sergheraert, Christian
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 13 p. 4490 - 4518
反应条件
1: dichloromethane / 20 °C 2: ammonia / -33 °C 3: CuSO4‵5H2O / tetrahydrofuran; water / 2 h / Reflux View Scheme
参考文献
Kowalkowska, Anna; Jonczyk, Andrzej
Synthetic Communications, 2011 , vol. 41, # 22 p. 3308 - 3317
反应条件
1.1: dichloromethane / 20 °C 2.1: triethylamine / dichloromethane / 2 h / 20 °C 2.2: 2 h / Reflux View Scheme
参考文献
Kowalkowska, Anna; Jonczyk, Andrzej
Synthetic Communications, 2011 , vol. 41, # 22 p. 3308 - 3317
反应条件
sodium hydroxide; tetrabutylammomium bromide in dichloromethane; water T=20°C; 16 h;
参考文献
Meyer; Joussef; Gallardo; De Souza, L. De B. P.
Synthetic Communications, 2004 , vol. 34, # 5 p. 783 - 793
反应条件
1: water; toluene / 6 h / 0 - 20 °C 2: dichloromethane / 12 h / Inert atmosphere; Reflux View Scheme
参考文献
Tayama, Eiji; Sato, Ryota; Takedachi, Keisuke; Iwamoto, Hajime; Hasegawa, Eietsu
Tetrahedron, 2012 , vol. 68, # 24 p. 4710 - 4718
反应条件
pyridine in toluene T=80°C; 2 h;
参考文献
Kerdesky, Francis A. J.; Holms, James H.; Moore, Jimmie L.; Bell, Randy L.; Dyer, Richard D.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2158 - 2165
反应条件
1: KF, AcNH2 / 6 h / 120 °C 2: KOH / methanol 3: SOCl2 / CHCl3 / Heating 4: NH3 / H2O 5: P2O5 / 100 - 107 °C / 3.5 Torr View Scheme
参考文献
Farmaco, Edizione Scientifica, , vol. 23, p. 1127 - 1140
反应条件
1: NaOMe 2: liq. NH3 3: POCl3, Py View Scheme
参考文献
Asthana,T.C. et al.
Indian Journal of Chemistry, 1970 , vol. 8, p. 1086 - 1095
