alpha-溴苯基乙酸甲酯合成路线 （共 64 条）
反应条件
2: dimethylformamide / Heating View Scheme
参考文献
Nesmeyanov,N.A. et al.
Zhurnal Organicheskoi Khimii, 1968 , vol. 4, # 3 p. 385 - 389,377 - 381
反应条件
silver trifluoromethanesulfonate in dichloromethane T=-78 - 23°C; 20 h; Inert atmosphere;
参考文献
Lai, Ping-Shan; Dubland, Joshua A.; Sarwar, Mohammed G.; Chudzinski, Michael G.; Taylor, Mark S.
Tetrahedron, 2011 , vol. 67, # 39 p. 7586 - 7592
反应条件
2,2'-azo-bisisobutyronitrile in benzene 5 h; Heating;
参考文献
Stien, Didier; Gastaldi, Stephane
Journal of Organic Chemistry, 2004 , vol. 69, # 13 p. 4464 - 4470
反应条件
1: Cs2CO3 / dimethylformamide 2: Ph3P, CBr4 / CH2Cl2 3: Cs2CO3 / dimethylformamide 4: 1 N aq. NaOH / methanol View Scheme
参考文献
Dhanoa; Bagley; Chang; Lotti; Chen; Kivlighn; Zingaro; Siegl; Chakravarty; Patchett; Greenlee
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3738 - 3742
反应条件
1: 1.) potassium iodide, anhydrous potassium carbonate; 2.) sodium methoxyde / 1.) acetone, reflux, 12 h; 2.) benzene, reflux, 7 h 2: 52 percent / lithium aluminium hydride / tetrahydrofuran / 0 deg C, reflux, 24 h View Scheme
参考文献
Olagbemiro, T.O.; Nyakutse, C.A.; Lajide, L.; Agho, M.O.; Chukwu, C.E.
Bulletin des Societes Chimiques Belges, 1987 , vol. 96, # 6 p. 473 - 480
反应条件
Sodium bromate; sodium hydrogensulfite in water; ethyl acetate
T=20°C; Bromination; 6 h;
参考文献
Kikuchi, Daisuke; Sakaguchi, Satoshi; Ishii, Yasutaka
Journal of Organic Chemistry, 1998 , vol. 63, # 17 p. 6023 - 6026
反应条件
bromocyane in dichloromethane
T=20°C; 12 h; Inert atmosphere;
参考文献
Tayama, Eiji; Sato, Ryota; Takedachi, Keisuke; Iwamoto, Hajime; Hasegawa, Eietsu
Tetrahedron, 2012 , vol. 68, # 24 p. 4710 - 4718
反应条件
sulfuric acid in ethanol
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1323716 A1, 2003 ;
反应条件
sulfuric acid
T=20°C; 1 h; Heating / reflux;
参考文献
Takeda Chemical Industries, Ltd.
Patent: US7008950 B1, 2006 ;
Location in patent: Page/Page column 37 ;
反应条件
sulfuric acid
T=80°C; 15 h; Inert atmosphere;
参考文献
Lai, Ping-Shan; Dubland, Joshua A.; Sarwar, Mohammed G.; Chudzinski, Michael G.; Taylor, Mark S.
Tetrahedron, 2011 , vol. 67, # 39 p. 7586 - 7592
