alpha-溴苯基乙酸甲酯合成路线 （共 64 条）
参考文献
Bravo,P. et al.
Tetrahedron Letters, 1968 , p. 4481 - 4484
反应条件
sodium methylate; potassium carbonate; potassium iodide
1.) acetone, reflux, 12 h; 2.) benzene, reflux, 7 h; Yield given. Multistep reaction;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/93470 A1, 2007 ;
Location in patent: Page/Page column 102-103 ;
US 20070093470 A1
反应条件
1: 2,2'-dinitrodiphenyl disulphide With samarium diiodide in tetrahydrofuran
T=20°C; 0.166667 h;
2: α-Bromo-benzeneacetic acid methyl ester in tetrahydrofuran
T=60°C; 4 h;
参考文献
Zhong, Weihui; Zhang, Yongmin
Tetrahedron Letters, 2001 , vol. 42, # 17 p. 3125 - 3127
反应条件
silver trifluoromethanesulfonate in dichloromethane
T=-78 - 23°C; Friedel Crafts alkylation; 20 h; Inert atmosphere;
参考文献
Lai, Ping-Shan; Dubland, Joshua A.; Sarwar, Mohammed G.; Chudzinski, Michael G.; Taylor, Mark S.
Tetrahedron, 2011 , vol. 67, # 39 p. 7586 - 7592
