[3-[3,4-二(羧甲基)苯基]-1-羟基-1-氧代丙烷-2-基]铵氯化物合成路线 (共 2 条)
反应条件
1: 3-(3,4-dihydroxyphenyl)-L-alanine With hydrogenchloride; acetic acid
T=20°C; 5 h;
2: acetic anhydride T=20 - 54°C; 2 h;
参考文献
HANWHA CHEMICAL CORPORATION; Park, Ju Young; Myeong, Wan Jae; Jeon, Bong-Sik; Kim, Eung Gyu; Kwon, Eun Byul; Hyeon, Taeghwan; Ling, Daishun
Patent: US2014/23594 A1, 2014 ;
Location in patent: Paragraph 0065 ;
反应条件
in acetic acid
T=45°C;
参考文献
Chavis; Grodenic; Imbach
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 3 p. 219 - 227