1: With tri-isopropoxy-borane; tert.-butyl lithium in tetrahydrofuran T=-78 - 20°C; 2: With hydrogenchloride; water in tetrahydrofuran

1: 5-bromo-isoquinoline With n-butyllithium in tetrahydrofuran T=-78°C; 0.75 h; 2: tri-isopropoxy-borane in tetrahydrofuran T=-78 - 20°C; 1.08333 h; 3: With sodium hydroxide; water in tetrahydrofuran

1: 5-bromo-isoquinoline With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.75 h; 2: boric acid trimethyl ester in tetrahydrofuran; hexane T=-78 - 20°C;

1: With sodium carbonate; Pd(Ph3P)4 in ethylene glycol dimethyl ether Suzuki cross-coupling reaction; 48 h; Heating; 2: in tetrahydrofuran 1 h;