Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Zakharkin, L. I.; Churilova, I. M.; Ovseenko, S. T.
Journal of Organic Chemistry USSR (English Translation), 1990 , vol. 26, # 9.2 p. 1696 - 1699
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1: anhydrous cyanoacetic acid With potassium hydroxide in water T=5°C; 0.25 h; 2: isobutyraldehyde With hydrogen; 5 palladium on charcoal in water P=750.075 Torr; 17 h; 3: With hydrogenchloride in water T=5°C; 0.25 h;
参考文献
PFIZER MANUFACTURING IRELAND; BURRELL, Adam James Musgrave; MARTINEZ, Carlos Alberto; MCDAID, Paul Oliver; O'NEILL, Padraig Mary; WONG, John Wing
Patent: WO2012/25861 A1, 2012 ;
Location in patent: Page/Page column 23-24 ;
WO 2012/025861 A1
diisopropyl-carbodiimide in N,N-dimethyl-formamide T=0 - 20°C; 1 h;
参考文献
Sjogren, Eric B.; Rider, Michael A.; Nelson, Peter H.; Bingham, Stanford; Poulton, Anthony L.; et al.
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