3-氟苯胺合成路线

919081-42-8(S)-3-(3-氟苯基)-5-羟甲基恶唑烷-2-酮

参考文献

Ali, Akbar; Reddy, G. S. Kiran Kumar; Cao, Hong; Anjum, Saima Ghafoor; Nalam, Madhavi N. L.; Schiffer, Celia A.; Rana, Tariq M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7342 - 7356

372-19-03-氟苯胺

391-83-37-氟-4-羟基喹啉

参考文献

Loewe, Werner; Dietz, Martin
Scientia Pharmaceutica, 1996 , vol. 64, # 3/4 p. 555 - 564

372-19-03-氟苯胺

116434-95-85-氟-3,4-二氢-1H-喹啉-2-酮+

4590-52-77-氟-3,4-二氢-2(1h)-喹啉酮

参考文献

F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; FANTASIA, Serena Maria; HORNSPERGER, Benoit; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander, V.; MOHR, Peter; SCALONE, Michelangelo; TAN, Xuefei; ZHOU, Mingwei
Patent: WO2013/41591 A1, 2013 ;

372-19-03-氟苯胺

4590-52-77-氟-3,4-二氢-2(1h)-喹啉酮

参考文献

MERCK SHARP and DOHME CORP.; ElexoPharm GmbH; HOYT, Scott, B.; PETRILLI, Whitney Lane; LONDON, Clare; XIONG, Yusheng; TAYLOR, Jerry Andrew; ALI, Amjad; LO, Michael; HENDERSON, Timothy, J.; HU, Qingzhong; HARTMANN, Rolf; YIN, Lina; HEIM, Ralf; BEY, Emmanuel; SAXENA, Rohit; SAMANTA, Swapan Kumar; KULKARNI, Bheemashankar, A.
Patent: WO2012/148808 A1, 2012 ;
WO 2012/148808 A1

372-19-03-氟苯胺+

821-48-7二(2-氯乙基)胺盐酸盐

3801-89-61-(3-氟苯基)哌嗪

参考文献

Martin; Elgin Jr.; Mathiasen; Davis; Kesslick; Baldy; Shank; DiStefano; Fedde; Scott
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1052 - 1056

458-05-91-(3-氟苯基)-2-硫脲

参考文献

Tremont, Samuel J.; Koeller, Kevin J.; Neumann, William L.
Patent: US2002/183307 A1, 2002 ;

372-19-03-氟苯胺+

1147550-11-5

458-05-91-(3-氟苯基)-2-硫脲

参考文献

Wang, Min; Gao, Mingzhang; Mock, Bruce H.; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8599 - 8607

372-19-03-氟苯胺

458-05-91-(3-氟苯基)-2-硫脲

参考文献

Bayer Aktiengesellschaft
Patent: US5356864 A1, 1994 ;

458-05-91-(3-氟苯基)-2-硫脲

参考文献

Hay, Michael P.; Turcotte, Sandra; Flanagan, Jack U.; Bonnet, Muriel; Chan, Denise A.; Sutphin, Patrick D.; Nguyen, Phuong; Giaccia, Amato J.; Denny, William A.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 787 - 797

参考文献

Attina, Marina; Cacace, Fulvio; de Petris, Giulia
Journal of the American Chemical Society, 1985 , vol. 107, p. 1556 - 1561