1.1: sodium sulfate / water / 1.33 h / 45 - 50 °C / Large scale reaction 1.2: 0.33 h / 50 - 55 °C / Large scale reaction 1.3: 8 h / 55 °C / Large scale reaction 2.1: sulfuric acid / water / 6.5 h / 58 - 62 °C / Large scale reaction 3.1: sodium hydroxide / water / 0.67 h / 25 °C / Large scale reaction 3.2: 2.5 h / 20 - 25 °C / Large scale reaction View Scheme
参考文献
JANSSEN PHARMACEUTICA NV; MEERPOEL, Lieven; MAES, Louis, Jules, Roger, Marie; DE WIT, Kelly
Patent: WO2012/69380 A1, 2012 ;
1.1: sodium sulfate / water / 1.33 h / 45 - 50 °C / Large scale reaction 1.2: 0.33 h / 50 - 55 °C / Large scale reaction 1.3: 8 h / 55 °C / Large scale reaction 2.1: sulfuric acid / water / 6.5 h / 58 - 62 °C / Large scale reaction View Scheme
参考文献
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