1.1: sodium sulfate / water / 1.33 h / 45 - 50 °C / Large scale reaction 1.2: 0.33 h / 50 - 55 °C / Large scale reaction 1.3: 8 h / 55 °C / Large scale reaction 2.1: sulfuric acid / water / 6.5 h / 58 - 62 °C / Large scale reaction 3.1: sodium hydroxide / water / 0.67 h / 25 °C / Large scale reaction 3.2: 2.5 h / 20 - 25 °C / Large scale reaction 4.1: 1-methyl-pyrrolidin-2-one / tert-butyl methyl ether / Large scale reaction 4.2: 1 h / 3 °C / Large scale reaction 4.3: 2.58 h / 2 °C / Large scale reaction 5.1: N-ethyl-N,N-diisopropylamine / V methoxymethyl ester; toluene / 40 - 123 °C / Large scale reaction 6.1: sodium hydride / N,N-dimethyl acetamide / 1 h / 17 - 22 °C / Large scale reaction 6.2: 17 h / 11 - 90 °C / Large scale reaction View Scheme

in ethanol 2 h; Heating / reflux;

in benzene 0.0833333 h; Reflux;

triethylamine in dichloromethane T=0 - 20°C;

acetic acid in ethanol