反应条件
1: 2-fluoro-pyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; diethyl ether T=-60°C; 1 h; Inert atmosphere; 2: tri-isopropoxy-borane in tetrahydrofuran; diethyl ether T=-60 - 20°C; Inert atmosphere; 3: 2,3-dimethylbutane-2,3-diol With acetic acid in tetrahydrofuran; diethyl ether T=20°C; Inert atmosphere;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; LI, Jijun; ZHU, Yan; HU, Yuandong; WANG, Huting; WANG, Zhe; WANG, Zanping; WEI, Yongheng; SUN, Yinghui; WU, Qiong; ZHANG, Hui; PENG, Yong; KONG, Fansheng; SUN, Ying; LUO, Hong; HAN, Yongxin
Patent: WO2013/71865 A1, 2013 ;
Location in patent: Page/Page column 27 ;