6-氨基-2-甲基-2-庚醇合成路线 （共 11 条）
反应条件
2,2,2-trifluoroethyl mercaptan in tetrahydrofuran; 3-methyl pentan-3-ol T=22 - 24°C; 2 h; Photolysis;
参考文献
El Blidi, Lahssen; Nechab, Malek; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Journal of Organic Chemistry, 2009 , vol. 74, # 7 p. 2901 - 2903
反应条件
methanol; nickel T=60°C; P=80905.8 Torr; Hydrogenation;
参考文献
Fujita et al.
Ann. Rep. Tanabe pharm. Res.Chem.Abstr., 1959 , vol. 4, # 2 p. 15,19
Ann. Rep. Tanabe pharm. Res.Chem.Abstr., 1960 , p. 8627
参考文献
Doeuvre; Poizat
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1947 , vol. 224, p. 288
反应条件
1: 180 °C 2: concentrated HCl View Scheme
参考文献
Doeuvre; Poizat
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1947 , vol. 224, p. 288
反应条件
1: in acetonitrile 2 h; Heating / reflux; 2: With Dowex Marathon C ion exchange resin in methanol; water 0.25 h; Acidic conditions;
参考文献
Neurochem (International) Limited
Patent: US2006/223855 A1, 2006 ;
Location in patent: Page/Page column 141-142 ;
反应条件
Alkaline protease in 3-methyl pentan-3-ol T=20°C; 1 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Nechab, Malek; El Blidi, Lahssen; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 21 p. 3917 - 3920
反应条件
coated protease in 3-methyl pentan-3-ol T=21°C; 72 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Queyroy, Severine; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 9 p. 1759 - 1764
反应条件
Candida antarctica lipase B in n-heptane T=80°C; 72 h; Title compound not separated from byproducts.;
参考文献
Routaboul, Lucie; Vanthuyne, Nicolas; Gastaldi, Stephane; Gil, Gerard; Bertrand, Michele
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 364 - 368
反应条件
alkaline protease in 3-methyl pentan-3-ol T=18 - 24°C; 1.5 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
El Blidi, Lahssen; Nechab, Malek; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Journal of Organic Chemistry, 2009 , vol. 74, # 7 p. 2901 - 2903
参考文献
Ciba-Geigy AG
Patent: US4661601 A1, 1987 ;
