4,6-二羟基吡嗪-3-羧酸甲酯合成路线 （共 3 条）
反应条件
trichlorophosphate T=95°C; 5 h;
参考文献
US2013/178478 A1, ;
Paragraph 0301;0302 ;
反应条件
1: With triphenylphosphine in diethyl ether
T=20°C; 24 h;
2: With acetic acid in water
10 h; Reflux;
参考文献
Hoffman-La Roche Inc.; Hermann, Johannes Cornelius; Kennedy-Smith, Joshua; Lucas, Matthew C.; Padilla, Fernando; Soth, Michael
Patent: US2013/178478 A1, 2013 ;
Location in patent: Paragraph 0299;0300 ;
反应条件
1.1: triethylamine; 4-Acetylaminobenzenesulfonyl Azide / acetonitrile / 1 h / 0 - 20 °C
2.1: triphenylphosphine / diethyl ether / 24 h / 20 °C
2.2: 10 h / |Reflux
View Scheme
参考文献
Hoffman-La Roche Inc.; Hermann, Johannes Cornelius; Kennedy-Smith, Joshua; Lucas, Matthew C.; Padilla, Fernando; Soth, Michael
Patent: US2013/178478 A1, 2013 ;
