2-氟-4-硝基硫代苯甲醚合成路线 （共 4 条）
反应条件
1.1: iron; acetic acid / water / |Inert atmosphere 2.1: sulfuric acid; sodium nitrite / tetrahydrofuran; water / 3 h / 0 °C / |Inert atmosphere 2.2: kappa (II) nitrate; kappa (I) oxide / 0.5 h / 20 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; ACTON, John, J.; EDMONDSON, Scott, D.; LIU, Ping; MILLER, Michael, W.; WOOD, Harold, B.; DUBOIS, Byron, G.; GEISS, William, B.
Patent: WO2014/52379 A1, 2014 ;
反应条件
in tetrahydrofuran; DMF (N,N-dimethyl-formamide)
T=20°C; 6.16667 h;
参考文献
CJ Corp.
Patent: US6849652 B1, 2005 ;
Location in patent: Page/Page column 7-8; 11 ;
反应条件
water; iron; acetic acid
2 h;
参考文献
Erickson, Shawn David; Gillespie, Paul; Guertin, Kevin Richard; Karnachi, Prabha Saba; Kim, Kyungjin; Ma, Chun; McComas, Warren William; Pietranico-Cole, Sherrie Lynn; Qi, Lida; Tilley, Jefferson Wright; Zhang, Qiang
Patent: US2009/286812 A1, 2009 ;
Location in patent: Page/Page column 19 ;
反应条件
1.1: iron; acetic acid / water / |Inert atmosphere
2.1: sulfuric acid; sodium nitrite / tetrahydrofuran; water / 3 h / 0 °C / |Inert atmosphere
2.2: kappa (II) nitrate; kappa (I) oxide / 0.5 h / 20 °C
3.1: Oxonereg; / tetrahydrofuran; water / 3 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; ACTON, John, J.; EDMONDSON, Scott, D.; LIU, Ping; MILLER, Michael, W.; WOOD, Harold, B.; DUBOIS, Byron, G.; GEISS, William, B.
Patent: WO2014/52379 A1, 2014 ;
