2-(4-氟苯基)-6-(三氟甲基)吡唑并[1,5-a]吡啶合成路线 （共 7 条）
反应条件
N-bromosuccinmide in tetrahydrofuran
参考文献
Cheung, Mui; Harris, Philip A.; Badiang, Jennifer G.; Peckham, Gregory E.; Chamberlain, Stanley D.; Alberti, Michael J.; Jung, David K.; Harris, Stephanie S.; Bramson, Neal H.; Epperly, Andrea H.; Stimpson, Stephen A.; Peel, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5428 - 5430
反应条件
in 1,2,4-trichloro-benzene
T=200°C; 10 h;
参考文献
AVIGEN, INC.
Patent: WO2007/146087 A2, 2007 ;
Location in patent: Page/Page column 55 ;
反应条件
1: 88 percent / aq. NaOH; NH2OH*HCl / methanol / 2 h / Heating
2: 82 percent / trifluoroacetic anhydride; Et3N / CH2Cl2 / 0.5 h / 0 °C
3: 71 percent / various solvent(s) / 10 h / 200 °C
View Scheme
参考文献
Stevens, Kirk L.; Jung, David K.; Alberti, Michael J.; Badiang, Jennifer G.; Peckham, Gregory E.; Veal, Jim M.; Cheung, Mui; Harris, Philip A.; Chamberlain, Stanley D.; Peel, Michael R.
Organic Letters, 2005 , vol. 7, # 21 p. 4753 - 4756
反应条件
1: 82 percent / trifluoroacetic anhydride; Et3N / CH2Cl2 / 0.5 h / 0 °C
2: 71 percent / various solvent(s) / 10 h / 200 °C
View Scheme
参考文献
Stevens, Kirk L.; Jung, David K.; Alberti, Michael J.; Badiang, Jennifer G.; Peckham, Gregory E.; Veal, Jim M.; Cheung, Mui; Harris, Philip A.; Chamberlain, Stanley D.; Peel, Michael R.
Organic Letters, 2005 , vol. 7, # 21 p. 4753 - 4756
反应条件
1: 73 percent / NaH / tetrahydrofuran / 72 h / 20 °C
2: 88 percent / aq. NaOH; NH2OH*HCl / methanol / 2 h / Heating
3: 82 percent / trifluoroacetic anhydride; Et3N / CH2Cl2 / 0.5 h / 0 °C
4: 71 percent / various solvent(s) / 10 h / 200 °C
View Scheme
参考文献
Stevens, Kirk L.; Jung, David K.; Alberti, Michael J.; Badiang, Jennifer G.; Peckham, Gregory E.; Veal, Jim M.; Cheung, Mui; Harris, Philip A.; Chamberlain, Stanley D.; Peel, Michael R.
Organic Letters, 2005 , vol. 7, # 21 p. 4753 - 4756
反应条件
1: 73 percent / NaH / tetrahydrofuran / 72 h / 20 °C
2: 88 percent / aq. NaOH; NH2OH*HCl / methanol / 2 h / Heating
3: 82 percent / trifluoroacetic anhydride; Et3N / CH2Cl2 / 0.5 h / 0 °C
4: 71 percent / various solvent(s) / 10 h / 200 °C
View Scheme
参考文献
Stevens, Kirk L.; Jung, David K.; Alberti, Michael J.; Badiang, Jennifer G.; Peckham, Gregory E.; Veal, Jim M.; Cheung, Mui; Harris, Philip A.; Chamberlain, Stanley D.; Peel, Michael R.
Organic Letters, 2005 , vol. 7, # 21 p. 4753 - 4756
反应条件
sodium hydroxide in methanol
Reflux;
参考文献
Cheung, Mui; Harris, Philip A.; Badiang, Jennifer G.; Peckham, Gregory E.; Chamberlain, Stanley D.; Alberti, Michael J.; Jung, David K.; Harris, Stephanie S.; Bramson, Neal H.; Epperly, Andrea H.; Stimpson, Stephen A.; Peel, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5428 - 5430
