sodium hydroxide; tetrabutylammomium bromide in tetrahydrofuran; water; toluene T=25°C; 23 h; Product distribution / selectivity;

1: 3-methylamino-4,4,4-trifluorocrotonic acid ethyl ester With potassium tert-butylate in N,N-dimethyl-formamide T=40 - 45°C; 0.583333 h; 2: N-(2-chloro-4-fluoro-5-isocyanatobenzoyl)-N'-methyl-(1-methylethyl)sulfamide in N,N-dimethyl-formamide T=-15 - 22°C;

potassium hydroxide; tetrabutylammomium bromide in tetrahydrofuran; water; toluene T=25 - 40°C; pH=5.3 - 5.5; 4 h; Product distribution / selectivity;

1: 3-methylamino-4,4,4-trifluorobut-2-enoic acid ethyl ester in DMF (N,N-dimethyl-formamide); pentane 0.75 h; Heating / reflux; 2: With potassium tert-butylate in DMF (N,N-dimethyl-formamide) T=40 - 45°C; 0.583333 h; 3: N-(2-chloro-4-fluoro-5-isocyanatobenzoyl)-N'-methyl-(1-methylethyl)sulfamide in DMF (N,N-dimethyl-formamide) T=-15 - 22°C; 1.03333 h; Product distribution / selectivity;

sodium hydroxide; tetrabutylammomium bromide in water; N,N-dimethyl-formamide T=25 - 40°C; pH=5.3 - 5.5; 6 h; Product distribution / selectivity;