1: 81 percent / LiBH4 / diethyl ether; tetrahydrofuran / 18 h / Ambient temperature 2: 3M HCl / methanol / 1 h / Heating 3: 80 percent / Ph3P, DEAD / tetrahydrofuran / 1.5 h / Ambient temperature View Scheme

1.1: hydrogen; 10 Pd/C / ethyl acetate / 20 °C / 750.08 Torr 2.1: trimethylaluminum / dichloromethane; hexane / 0 - 20 °C / |Inert atmosphere 2.2: |Inert atmosphere 3.1: (R)-3,3′-bis[3,5-bis(trifluoromethyl)phenyl]-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate / cyclohexane / 60 h / 20 °C / |Molecular sieve 4.1: hydrogen / acetone View Scheme

1.1: trimethylaluminum / dichloromethane; hexane / 0 - 20 °C / |Inert atmosphere 1.2: |Inert atmosphere 2.1: (R)-3,3′-bis[3,5-bis(trifluoromethyl)phenyl]-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate / cyclohexane / 60 h / 20 °C / |Molecular sieve 3.1: hydrogen / acetone View Scheme

1: (R)-3,3′-bis[3,5-bis(trifluoromethyl)phenyl]-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate / cyclohexane / 60 h / 20 °C / |Molecular sieve 2: hydrogen / acetone View Scheme

1.1: potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 °C 2.1: hydrogen; 10 Pd/C / ethyl acetate / 20 °C / 750.08 Torr 3.1: trimethylaluminum / dichloromethane; hexane / 0 - 20 °C / |Inert atmosphere 3.2: |Inert atmosphere 4.1: (R)-3,3′-bis[3,5-bis(trifluoromethyl)phenyl]-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate / cyclohexane / 60 h / 20 °C / |Molecular sieve 5.1: hydrogen / acetone View Scheme

sodium hydroxide