(氯亚甲基)二甲基氯化铵合成路线 （共 84 条）
反应条件
in acetonitrile T=10°C; Vilsmeier formylation;
参考文献
Marcin, Lawrence R.; Denhart, Derek J.; Mattson, Ronald J.
Organic Letters, 2005 , vol. 7, # 13 p. 2651 - 2654
反应条件
technical pyridine base mixture Yield given. Title compound not separated from byproducts;
参考文献
Niedrich; Heyne; Schrotter; et al.
Pharmazie, 1986 , vol. 41, # 3 p. 173 - 175
反应条件
1: N-(chloromethylene)-N-methylmethanaminium chloride; N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide in acetonitrile 0.916667 h; 2: 5-Fluoro-1,3-dihydro-2H-indol-2-one With potassium hydroxide in acetonitrile T=20°C; 3.5 h;
参考文献
Pharmacia and Upjohn Company LLC
Patent: US2006/9510 A1, 2006 ;
Location in patent: Page/Page column 16 ;
反应条件
in diethyl ether; chloroform T=-65°C;
参考文献
Stojanovic,F.M.; Arnold,Z.
Collection of Czechoslovak Chemical Communications, 1967 , vol. 32, p. 2155 - 2160
反应条件
1: in N,N-dimethyl-formamide T=10 - 30°C; 2: With hydrogenchloride; water in N,N-dimethyl-formamide Reflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 18, # 9 p. 3036 - 3042
反应条件
in toluene 1.) 2 h, RT, 2.) 2 h, reflux;
参考文献
Stanovnik, Branko; Bajt, OLiver; Balcic, Branko; Koren, Bozidar; Prhavc, Marija; et al.
Heterocycles, 1984 , vol. 22, # 7 p. 1545 - 1554
参考文献
Morita et al.
Chemical and Pharmaceutical Bulletin, 1959 , vol. 7, p. 896
反应条件
in toluene 1.) RT, 2.) reflux;
参考文献
Stanovnik, Branko; Bajt, OLiver; Balcic, Branko; Koren, Bozidar; Prhavc, Marija; et al.
Heterocycles, 1984 , vol. 22, # 7 p. 1545 - 1554
反应条件
in N,N-dimethyl-formamide T=60 - 70°C; 1 h;
参考文献
Barrio, Jorge R.; Petric, Andre J.; Satyamurthy, Nagichettiar; Kepe, Vladimir; Small, Gary W.
Patent: US2007/53831 A1, 2007 ;
Location in patent: Page/Page column 11 ;
反应条件
1: T=100°C; Vilsmeier-Haack reaction; 3.5 h; Inert atmosphere; 2: With water T=20°C;
参考文献
Lopez, Sergio; McCabe, Thomas; Stanley McElhinney; McMurry, T. Brian H.; Rozas, Isabel
Tetrahedron Letters, 2009 , vol. 50, # 44 p. 6022 - 6024
