(氯亚甲基)二甲基氯化铵合成路线 （共 84 条）
反应条件
in tetrahydrofuran byproducts: NaCl; Addn. of (Me2NCHCl)Cl to soln. of Mn-complex under N2 with stirring, color changes to orange red.; Filtn., evapn. of solvent, dissolving in toluene, column chromy. (SiO2, 5°C, toluene), evapn. of the second zone in vac., recrystn. (pentane, -78°C), elem. anal.;
参考文献
Kirchgaessner, Uwe; Piana, Hermann; Schubert, Ulrich
Journal of the American Chemical Society, 1991 , vol. 113, # 6 p. 2228 - 2232
反应条件
in tetrahydrofuran addn. of (CH3)2NC(H)Cl2 to soln. of K salt (equimolar amounts) in THF at 0°C under stirring and under N2;; filtration after 10 min; concn.; chromy. (silica, -15°C, toluene: isolation of Cr hydride, then ether); evapn. in vac. to dryness; addn. of ether; recrystn. from toluene/petroleum ether;;
参考文献
Schubert, Juergen; Mock, Stefan; Schubert, Ulrich
Chemische Berichte, 1993 , vol. 126, # 3 p. 657 - 664
反应条件
sodium ethanolate in chloroform
参考文献
Eilingsfeld,H. et al.
Chemische Berichte, 1963 , vol. 96, p. 2671 - 2690
反应条件
1: in N,N-dimethyl-formamide T=75°C; Vilsmeier formylation; 16 h; 2: With sodium hydroxide
参考文献
Cooper, Laura C.; Chicchi, Gary G.; Dinnell, Kevin; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Locker, Karen L.; Morrison, Denise; Shaw, Duncan E.; Tsao, Kwei-Lan; Watt, Alan P.; Williams, Angela R.; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1233 - 1236
反应条件
in acetonitrile T=-10°C;
参考文献
Dulcere, Jean-Pierre
Tetrahedron Letters, 1981 , vol. 22, # 17 p. 1599 - 1600
反应条件
1: T=-10°C; 2: With sodium hydroxide in water pH=3; Cooling with ice;
参考文献
Organic Process Research and Development, , vol. 16, # 1 p. 57 - 60
反应条件
sodium hydroxide 1) DMF, 20 deg C, 18 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tetrahedron, , vol. 49, # 19 p. 4015 - 4034
参考文献
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), , p. 348 - 356
反应条件
Vilsmeier formylation;
参考文献
Bandgar, Babasaheb P.; Hote, Baliram S.; Nile, Shivraj H.
Letters in Drug Design and Discovery, 2011 , vol. 8, # 8 p. 725 - 732
参考文献
Yoshihara, Masakuni; Eda, Tsunehito; Sakaki, Keishi; Maeshima, Toshihisa
Synthesis, 1980 , # 9 p. 746 - 748
