N-(6-甲酰基吡啶-2-基)三甲基乙酰胺合成路线 （共 6 条）
反应条件
1: With sodium tetrahydroborate in methanol 3 h; 2: With hydrogenchloride; water in methanol; ethyl acetate 3: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
PFIZER INC.
Patent: WO2006/106423 A2, 2006 ;
Location in patent: Page/Page column 33 ;
WO 2006/106423 A2
反应条件
silver nitrate in water; acetone
T=20°C; 12 h;
参考文献
Inomata, Tomohiko; Shinozaki, Kazuma; Hayashi, Yuya; Arii, Hidekazu; Funahashi, Yasuhiro; Ozawa, Tomohiro; Masuda, Hideki
Chemical Communications, 2008 , # 3 p. 392 - 394
反应条件
1: 2-bromo-6-N-pivaloylaminopyridine With isopropylmagnesium chloride in tetrahydrofuran; toluene
T=5°C; 24 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; toluene
T=10 - 15°C; 0.583333 h; Further stages.;
参考文献
Mase; Houpis; Akao; Dorziotis; Emerson; Hoang; Iida; Itoh; Kamei; Kato; Kawasaki; Lang; Lee; Lynch; Maligres; Molina; Nemoto; Okada; Reamer; Song; Tschaen; Wada; Zewge; Volante; Reider; Tomimoto
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6775 - 6786
反应条件
selenium(IV) oxide in acetic acid
0.416667 h; Heatingmicrowave;
参考文献
Goswami, Shyamaprosad; Adak, Avijit Kumar
Synthetic Communications, 2003 , vol. 33, # 3 p. 475 - 480
反应条件
1.1: 97.4 percent / Et3N / toluene / 25 h / 20 - 45 °C
2.1: i-PrMgCl / toluene; tetrahydrofuran / 24 h / 5 °C
2.2: 83 percent / toluene; tetrahydrofuran / 0.58 h / 10 - 15 °C
View Scheme
参考文献
Mase; Houpis; Akao; Dorziotis; Emerson; Hoang; Iida; Itoh; Kamei; Kato; Kawasaki; Lang; Lee; Lynch; Maligres; Molina; Nemoto; Okada; Reamer; Song; Tschaen; Wada; Zewge; Volante; Reider; Tomimoto
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6775 - 6786
反应条件
1.1: 97.4 percent / Et3N / toluene / 25 h / 20 - 45 °C
2.1: i-PrMgCl / toluene; tetrahydrofuran / 24 h / 5 °C
2.2: 83 percent / toluene; tetrahydrofuran / 0.58 h / 10 - 15 °C
View Scheme
参考文献
Mase; Houpis; Akao; Dorziotis; Emerson; Hoang; Iida; Itoh; Kamei; Kato; Kawasaki; Lang; Lee; Lynch; Maligres; Molina; Nemoto; Okada; Reamer; Song; Tschaen; Wada; Zewge; Volante; Reider; Tomimoto
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6775 - 6786
